Persistence with Antihypertensive Medications in Uncomplicated Treatment-Naive Patients: Effects of Initial Therapeutic Classes
DC Field | Value | Language |
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dc.contributor.author | Ah, Young-Mi | - |
dc.contributor.author | Lee, Ju-Yeun | - |
dc.contributor.author | Choi, Yun-Jung | - |
dc.contributor.author | Kim, Baegeum | - |
dc.contributor.author | Choi, Kyung Hee | - |
dc.contributor.author | Kong, Jisun | - |
dc.contributor.author | Oh, Jung Mi | - |
dc.contributor.author | Shin, Wan Gyoon | - |
dc.contributor.author | Lee, Hae-Young | - |
dc.date.accessioned | 2022-07-15T20:07:08Z | - |
dc.date.available | 2022-07-15T20:07:08Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155796 | - |
dc.description.abstract | We aimed to assess one-year persistence with antihypertensive therapy (AHT) among newly treated uncomplicated hypertensive patients in Korea and to evaluate the effect of initial therapeutic classes on persistence. We retrospectively analyzed a random sample of 20% of newly treated uncomplicated hypertensive patients (n = 45,787) in 2012 from the National Health Insurance claims database. This group was classified into six cohorts based on initial AHT class. We then measured treatment persistence, allowing a prescription gap of 60 days. Adherence to AHT was assessed with the medication possession ratio. Calcium channel blockers (CCB, 43.7%) and angiotensin receptor blockers (ARB, 40.3%) were most commonly prescribed as initial monotherapy. Overall, 62.1% and 42.0% were persistent with any AHT and initial class at one year, respectively, and 64.2% were adherent to antihypertensive treatment. Compared with ARBs, the risk of AHT discontinuation was significantly increased with initial use of thiazide diuretics (hazard ratio [HR], 3.16; 95% confidence interval [CI] 2.96-3.74) and beta blockers (HR, 1.86; CI, 1.77-1.95) and was minimally increased with CCBs (HR, 1.12; CI, 1.08-1.15). In conclusion, persistence and adherence to AHT are suboptimal, but the differences are meaningful in persistence and adherence between initial AHT classes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.title | Persistence with Antihypertensive Medications in Uncomplicated Treatment-Naive Patients: Effects of Initial Therapeutic Classes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Ju-Yeun | - |
dc.identifier.doi | 10.3346/jkms.2015.30.12.1800 | - |
dc.identifier.scopusid | 2-s2.0-84951761964 | - |
dc.identifier.wosid | 000368136400013 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.30, no.12, pp.1800 - 1806 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 30 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1800 | - |
dc.citation.endPage | 1806 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002055468 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | HYPERTENSIVE PATIENTS | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | BLOOD-PRESSURE | - |
dc.subject.keywordPlus | PRIMARY-CARE | - |
dc.subject.keywordPlus | DRUG-USE | - |
dc.subject.keywordPlus | ADHERENCE | - |
dc.subject.keywordPlus | DISCONTINUATION | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordAuthor | Uncomplicated Hypertension | - |
dc.subject.keywordAuthor | Persistence | - |
dc.subject.keywordAuthor | Adherence | - |
dc.subject.keywordAuthor | Therapeutic Class | - |
dc.identifier.url | https://jkms.org/DOIx.php?id=10.3346/jkms.2015.30.12.1800 | - |
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