Comparison of clinical outcomes between upgraded pathologic Gleason score 3 + 4 and non-upgraded 3 + 4 prostate cancer among patients who are candidates for active surveillance.
DC Field | Value | Language |
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dc.contributor.author | Jo, Jung Ki | - |
dc.contributor.author | Hong, Sung Kyu | - |
dc.contributor.author | Byun, Seok-Soo | - |
dc.contributor.author | Lee, Sang Eun | - |
dc.contributor.author | Oh, Jong Jin | - |
dc.date.accessioned | 2022-07-15T20:13:21Z | - |
dc.date.available | 2022-07-15T20:13:21Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.issn | 0724-4983 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155884 | - |
dc.description.abstract | To clarify differences patients with pathological GS (pGS) 3 + 4 according to biopsy Gleason score (bGS) after radical prostatectomy (RP) among candidates for active surveillance. Between January 2006 and June 2014, 619 patients who met Royal Marsden criteria and had a pGS 3 + 4 after RP were identified. Patients were stratified into two groups according to bGS: Group A (n = 430) with bGS (3 + 3) and Group B (n = 189) with bGS 7 (3 + 4). Pathological outcomes were compared between the two groups, and the impact of bGS on adverse pathological outcomes was analyzed by logistic regression and biochemical recurrence (BCR)-free survival compared by log-rank test and the Cox proportional hazards model. The patients in Group B had a higher rate of extracapsular extension (ECE), seminal vesicle invasion and positive surgical margins than those in Group A (p < 0.001, p = 0.005, p = 0.046, respectively). In univariate and multivariate, bGS was significantly associated with ECE [odds ratio (OR) 2.615, p < 0.001; OR 1.769, p < 0.001]. In Kaplan-Meier analysis, BCR-free survival rate was higher in Group A than in Group B (log rank, p = 0.037). In multivariable Cox regression, maximum percentage of core involvement were strongly associated with BCR [hazard ratio (HR) 1.773 (1.248-2.519), p = 0.001]. pGS 3 + 4 was associated with heterogeneous pathologic and biochemical outcomes according to bGS. Patients with pGS 3 + 4 upgraded from bGS 3 + 3 had more favorable pathological outcomes and biochemical survival outcomes than those with bGS 3 + 4. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.title | Comparison of clinical outcomes between upgraded pathologic Gleason score 3 + 4 and non-upgraded 3 + 4 prostate cancer among patients who are candidates for active surveillance. | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jo, Jung Ki | - |
dc.identifier.doi | 10.1007/s00345-015-1527-2 | - |
dc.identifier.scopusid | 2-s2.0-84945494117 | - |
dc.identifier.wosid | 000363719100011 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF UROLOGY, v.33, no.11, pp.1729 - 1734 | - |
dc.relation.isPartOf | WORLD JOURNAL OF UROLOGY | - |
dc.citation.title | WORLD JOURNAL OF UROLOGY | - |
dc.citation.volume | 33 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1729 | - |
dc.citation.endPage | 1734 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | RADICAL PROSTATECTOMY | - |
dc.subject.keywordPlus | JOHNS-HOPKINS | - |
dc.subject.keywordPlus | MEN | - |
dc.subject.keywordPlus | CRITERIA | - |
dc.subject.keywordPlus | UPDATE | - |
dc.subject.keywordAuthor | Prostatic neoplasms | - |
dc.subject.keywordAuthor | Prostatectomy | - |
dc.subject.keywordAuthor | Pathology | - |
dc.subject.keywordAuthor | Active surveillance | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s00345-015-1527-2?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot | - |
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