Correlation between F-18-FDG uptake on PET/CT and prognostic factors in triple-negative breast cancer
DC Field | Value | Language |
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dc.contributor.author | Koo, Hye Ryoung | - |
dc.contributor.author | Park, Jeong Seon | - |
dc.contributor.author | Kang, Keon Wook | - |
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Park, In Ae | - |
dc.contributor.author | Moon, Woo Kyung | - |
dc.date.accessioned | 2022-07-15T20:21:05Z | - |
dc.date.available | 2022-07-15T20:21:05Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/155982 | - |
dc.description.abstract | The purpose of this study was to investigate whether a correlation exists between F-18-fluorodeoxyglucose (FDG) uptake and prognostic factors in triple-negative breast cancer (TNBC). Between January 2009 and December 2013, 103 patients (mean age, 50.6 years) with primary TNBC (mean, 2.6 cm; range, 1.0-6.5 cm) underwent F-18-FDG PET/CT for initial staging. Correlations between maximum standardized uptake value (SUVmax) on PET/CT and prognostic factors including tumour size, nodal status, histological grade, Ki-67 proliferation index, tumour suppressor p53, and 'basal-like' markers (epidermal growth factor receptor and CK 5/6) were assessed. The mean SUVmax of the 103 tumours was 10.94 +/- 5.25 (range: 2-32.8). There was a positive correlation between SUVmax and Ki-67 (Spearman's rho = 0.29, P = 0.003) and tumour size (Spearman's rho = 0.27, P = 0.006), whereas this relationship was not observed in the nodal status, histological grade, p53 status and 'basal-like' phenotypes. In a multivariate regression analysis, Ki-67 (P < 0.001) and tumour size (P = 0.009) were significantly associated with SUVmax in TNBCs. Increased F-18-FDG uptake on PET/CT was correlated with a high Ki-67 proliferation index and larger tumour size in TNBC. These results suggest a potential role of F-18-FDG PET/CT in identifying TNBC with more aggressive behaviour. aEuro cent A wide range of FDG uptake reflected heterogeneity of cancer metabolism. aEuro cent FDG uptake was correlated with the Ki-67 proliferation index in TNBC. aEuro cent FDG uptake was correlated with tumour size in TNBC. aEuro cent FDG uptake was not correlated with 'basal-like' phenotype. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.title | Correlation between F-18-FDG uptake on PET/CT and prognostic factors in triple-negative breast cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Jeong Seon | - |
dc.identifier.doi | 10.1007/s00330-015-3734-z | - |
dc.identifier.scopusid | 2-s2.0-84943361914 | - |
dc.identifier.wosid | 000362518200022 | - |
dc.identifier.bibliographicCitation | EUROPEAN RADIOLOGY, v.25, no.11, pp.3314 - 3321 | - |
dc.relation.isPartOf | EUROPEAN RADIOLOGY | - |
dc.citation.title | EUROPEAN RADIOLOGY | - |
dc.citation.volume | 25 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3314 | - |
dc.citation.endPage | 3321 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | PATHOLOGICAL COMPLETE RESPONSE | - |
dc.subject.keywordPlus | NEOADJUVANT CHEMOTHERAPY | - |
dc.subject.keywordPlus | BASAL-LIKE | - |
dc.subject.keywordPlus | FDG UPTAKE | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | KI-67 | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | STRATEGIES | - |
dc.subject.keywordPlus | ANTIBODY | - |
dc.subject.keywordPlus | SUBTYPES | - |
dc.subject.keywordAuthor | Triple-negative breast cancer | - |
dc.subject.keywordAuthor | F-18-FDGPET/CT | - |
dc.subject.keywordAuthor | Immunohistochemistry | - |
dc.subject.keywordAuthor | Ki-67 proliferation index | - |
dc.subject.keywordAuthor | Cancer metabolism | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s00330-015-3734-z | - |
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