Biphasic reactions in patients with anaphylaxis treated with corticosteroids
- Authors
- Ko, Byuk Sung; Kim, Won Young; Ryoo, Seung Mok; Ahn, Shin; Sohn, Chang Hwan; Seo, Dong-Woo; Lee, Yoon-Seon; Lim, Kyoung Soo; Kim, Tae-Bum
- Issue Date
- Oct-2015
- Publisher
- ELSEVIER SCIENCE INC
- Citation
- ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, v.115, no.4, pp.312 - 316
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
- Volume
- 115
- Number
- 4
- Start Page
- 312
- End Page
- 316
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156127
- DOI
- 10.1016/j.anai.2015.07.015
- ISSN
- 1081-1206
- Abstract
- Background Although the incidence of anaphylaxis is rapidly increasing, the clinical characteristics and associated factors of a biphasic reaction are unclear. Objective To determine the incidence and clinical characteristics of biphasic reactions in patients with anaphylaxis treated with corticosteroids. Methods A total of 655 patients with anaphylaxis visiting the emergency department of a tertiary teaching hospital from January 2007 through December 2014 were analyzed. Patient characteristics, triggers, symptoms and signs, in-hospital management, and disposition were recorded. A biphasic reaction was defined as the development of anaphylaxis after complete resolution of the initial reaction without further exposure to the offending agent within 7 days. Univariate and multivariate analyses on the predictors of the biphasic reaction were performed. Results Of the 415 patients with anaphylaxis treated with corticosteroids, 9 patients (2.2%) developed a biphasic reaction. The mean age was 48.4 years, and 221 patients (54.4%) were women. The median time from complete resolution of initial clinical symptoms to occurrence of the biphasic reaction was 15 hours (range 1-45). History of drug anaphylaxis (odds ratio 14.3, 95% confidence interval 2.4-85.8) was a contributing factor to the development of the biphasic reaction. Conclusion The incidence of biphasic reactions was 2.2% in patients treated with corticosteroids and those with a history of drug anaphylaxis were at greater risk.
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