The neural basis of a deficit in abstract thinking in patients with schizophrenia
DC Field | Value | Language |
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dc.contributor.author | Oh, Jooyoung | - |
dc.contributor.author | Chun, Ji-Won | - |
dc.contributor.author | Jo, Hang Joon | - |
dc.contributor.author | Kim, Eunseong | - |
dc.contributor.author | Park, Hae-Jeong | - |
dc.contributor.author | Lee, Boreom | - |
dc.contributor.author | Kim, Jae-Jin | - |
dc.date.accessioned | 2022-07-15T20:42:33Z | - |
dc.date.available | 2022-07-15T20:42:33Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2015-10 | - |
dc.identifier.issn | 0925-4927 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156147 | - |
dc.description.abstract | Abnormal abstract thinking is a major cause of social dysfunction in patients with schizophrenia, but little is known about its neural basis. In this study, we aimed to determine the characteristic abstract thinking-related brain responses in patients using a task reflecting social situations. We conducted functional magnetic resonance imaging while 16 patients with schizophrenia and 16 healthy controls performed a theme-identification task, in which various emotional pictures depicting social situations were presented. Compared with healthy controls, the patients showed significantly decreased activity in the left frontopolar and right orbitofrontal cortices during theme identification. Activity in these two regions correlated well in the controls, but not in patients. Instead, the patients exhibited a close correlation between activity in both sides of the frontopolar cortex, and a positive correlation between the right orbitofrontal cortex activity and degrees of theme identification. Reduced activity in the left frontopolar and right orbitofrontal cortices and the underlying aberrant connectivity may be implicated in the patients' deficits in abstract thinking. These newly identified features of the neural basis of abnormal abstract thinking are important as they have implications for the impaired social behavior of patients with schizophrenia during real-life situations. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | The neural basis of a deficit in abstract thinking in patients with schizophrenia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jo, Hang Joon | - |
dc.identifier.doi | 10.1016/j.pscychresns.2015.08.007 | - |
dc.identifier.scopusid | 2-s2.0-84948710528 | - |
dc.identifier.wosid | 000365221500009 | - |
dc.identifier.bibliographicCitation | PSYCHIATRY RESEARCH-NEUROIMAGING, v.234, no.1, pp.66 - 73 | - |
dc.relation.isPartOf | PSYCHIATRY RESEARCH-NEUROIMAGING | - |
dc.citation.title | PSYCHIATRY RESEARCH-NEUROIMAGING | - |
dc.citation.volume | 234 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 66 | - |
dc.citation.endPage | 73 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neuroimaging | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | REDUCED FRONTOPOLAR ACTIVATION | - |
dc.subject.keywordPlus | DORSOLATERAL PREFRONTAL CORTEX | - |
dc.subject.keywordPlus | VERBAL FLUENCY TASK | - |
dc.subject.keywordPlus | WORKING-MEMORY | - |
dc.subject.keywordPlus | NEURODEVELOPMENTAL HYPOTHESIS | - |
dc.subject.keywordPlus | PHYSIOLOGICAL DYSFUNCTION | - |
dc.subject.keywordPlus | COGNITIVE CONTROL | - |
dc.subject.keywordPlus | SOCIAL COGNITION | - |
dc.subject.keywordPlus | CONCRETE | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordAuthor | Abstract thinking | - |
dc.subject.keywordAuthor | Theme identification | - |
dc.subject.keywordAuthor | Schizophrenia | - |
dc.subject.keywordAuthor | Frontopolar cortex | - |
dc.subject.keywordAuthor | Orbitofrontal cortex | - |
dc.subject.keywordAuthor | FMRI | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0925492715300615?pes=vor | - |
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