Stereotactic brain injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer's disease dementia: A phase 1 clinical trial
DC Field | Value | Language |
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dc.contributor.author | Kim, Hee Jin | - |
dc.contributor.author | Seo, Sang Won | - |
dc.contributor.author | Chang, Jong Wook | - |
dc.contributor.author | Lee, Jung Il | - |
dc.contributor.author | Kim, Chi Hun | - |
dc.contributor.author | Chin, Juhee | - |
dc.contributor.author | Choi, Soo Jin | - |
dc.contributor.author | Kwon, Hunki | - |
dc.contributor.author | Yun, Hyuk Jin | - |
dc.contributor.author | Lee, Jong Min | - |
dc.contributor.author | Kim, Sung Tae | - |
dc.contributor.author | Choe, Yearn Seong | - |
dc.contributor.author | Lee, Kyung-Han | - |
dc.contributor.author | Na, Duk L. | - |
dc.date.accessioned | 2022-07-15T20:45:40Z | - |
dc.date.available | 2022-07-15T20:45:40Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2015-10 | - |
dc.identifier.issn | 2352-8737 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156186 | - |
dc.description.abstract | Introduction We conducted a phase 1 clinical trial in nine patients with mild-to-moderate Alzheimer's disease to evaluate the safety and dose-limiting toxicity of stereotactic brain injection of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs). Methods The low- (n = 3) and high-dose (n = 6) groups received a total of 3.0 × 106 cells/60 μL and 6.0 × 106 cells/60 μL, respectively, into the bilateral hippocampi and right precuneus. Results No patient showed serious adverse events including fever during the 24-month follow-up period. During the 12-week follow-up period, the most common acute adverse event was wound pain from the surgical procedure (n = 9), followed by headache (n = 4), dizziness (n = 3), and postoperative delirium (n = 3). There was no dose-limiting toxicity. Discussion Administration of hUCB-MSCs into the hippocampus and precuneus by stereotactic injection was feasible, safe, and well tolerated. Further trials are warranted to test the efficacy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Inc. | - |
dc.title | Stereotactic brain injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer's disease dementia: A phase 1 clinical trial | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jong Min | - |
dc.identifier.doi | 10.1016/j.trci.2015.06.007 | - |
dc.identifier.scopusid | 2-s2.0-84944238723 | - |
dc.identifier.bibliographicCitation | Alzheimer's and Dementia: Translational Research and Clinical Interventions, v.1, no.2, pp.95 - 102 | - |
dc.relation.isPartOf | Alzheimer's and Dementia: Translational Research and Clinical Interventions | - |
dc.citation.title | Alzheimer's and Dementia: Translational Research and Clinical Interventions | - |
dc.citation.volume | 1 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 95 | - |
dc.citation.endPage | 102 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | aged | - |
dc.subject.keywordPlus | Alzheimer disease | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | asthenia | - |
dc.subject.keywordPlus | backache | - |
dc.subject.keywordPlus | clinical article | - |
dc.subject.keywordPlus | colon polyp | - |
dc.subject.keywordPlus | dizziness | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | follow up | - |
dc.subject.keywordPlus | headache | - |
dc.subject.keywordPlus | hippocampus | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | ligament injury | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mesenchymal stem cell transplantation | - |
dc.subject.keywordPlus | Mini Mental State Examination | - |
dc.subject.keywordPlus | nausea | - |
dc.subject.keywordPlus | nuclear magnetic resonance imaging | - |
dc.subject.keywordPlus | phase 1 clinical trial | - |
dc.subject.keywordPlus | postoperative complication | - |
dc.subject.keywordPlus | postoperative delirium | - |
dc.subject.keywordPlus | postoperative pain | - |
dc.subject.keywordPlus | postoperative wound pain | - |
dc.subject.keywordPlus | precuneus | - |
dc.subject.keywordPlus | preoperative evaluation | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | safety | - |
dc.subject.keywordPlus | stereotactic brain injection | - |
dc.subject.keywordPlus | stereotactic treatment | - |
dc.subject.keywordPlus | umbilical cord blood | - |
dc.subject.keywordPlus | vomiting | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | Hippocampus | - |
dc.subject.keywordAuthor | Mesenchymal stem cell | - |
dc.subject.keywordAuthor | Precuneus | - |
dc.subject.keywordAuthor | Stereotactic injection | - |
dc.identifier.url | https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1016/j.trci.2015.06.007 | - |
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