Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Prognostic Role of Serum Levels of Uric Acid in Amyotrophic Lateral Sclerosis

Full metadata record
DC Field Value Language
dc.contributor.authorOh, Seong-il-
dc.contributor.authorBaek, Soojeong-
dc.contributor.authorPark, Jin-Seok-
dc.contributor.authorPiao, Liying-
dc.contributor.authorOh, Ki-Wook-
dc.contributor.authorKim, Seung Hyun-
dc.date.accessioned2022-07-15T20:51:20Z-
dc.date.available2022-07-15T20:51:20Z-
dc.date.created2021-05-12-
dc.date.issued2015-10-
dc.identifier.issn1738-6586-
dc.identifier.urihttps://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156245-
dc.description.abstractBackground and Purpose It has been suggested that oxidative stress is one of the pathomechanisms underlying amyotrophic lateral sclerosis (ALS), and thus antioxidants such as uric acid (UA) that could reduce oxidative stress might be beneficial in the prevention or treatment of this disease. The objective of this study was to prospectively investigate serum UA levels in Korean ALS patients and to relate them to disease progression. Methods ALS patients and healthy controls who were individually well-matched for sex, age, and body mass index (BMI) underwent blood testing for serum UA levels, and analyzed whether UA levels were correlated with the disease status of the patients, as defined by the ALS Functional Rating Scale-Revised (ALSFRS-R). Results The study included 136 ALS patients and 136 matched controls. The UA level was lower in the ALS patients (4.50 +/- 1.17 mg/dL, mean +/- SD) than in the controls (5.51 +/- 1.22 mg/dL; p<0.001). Among the ALS patients, the level of UA acid was inversely correlated with the rate of disease progression (decrease in ALSFRS-R score). Kaplan-Meier analysis revealed that a better survival rate was more strongly correlated with top-tertile levels of serum UA than with bottom-tertile levels (log-rank test: p=0.035). Conclusions ALS patients had lower serum UA levels than did healthy individuals. UA levels in ALS were negatively correlated with the rate of disease progression and positively associated with survival, suggesting that UA levels contribute to the progression of ALS. UA levels could be considered a biomarker of disease progression in the early phase in ALS patients.-
dc.language영어-
dc.language.isoen-
dc.publisherKOREAN NEUROLOGICAL ASSOC-
dc.titlePrognostic Role of Serum Levels of Uric Acid in Amyotrophic Lateral Sclerosis-
dc.typeArticle-
dc.contributor.affiliatedAuthorPark, Jin-Seok-
dc.contributor.affiliatedAuthorOh, Ki-Wook-
dc.contributor.affiliatedAuthorKim, Seung Hyun-
dc.identifier.doi10.3988/jcn.2015.11.4.376-
dc.identifier.scopusid2-s2.0-84942783081-
dc.identifier.wosid000361926700011-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL NEUROLOGY, v.11, no.4, pp.376 - 382-
dc.relation.isPartOfJOURNAL OF CLINICAL NEUROLOGY-
dc.citation.titleJOURNAL OF CLINICAL NEUROLOGY-
dc.citation.volume11-
dc.citation.number4-
dc.citation.startPage376-
dc.citation.endPage382-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.identifier.kciidART002034549-
dc.description.journalClass1-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaNeurosciences & Neurology-
dc.relation.journalWebOfScienceCategoryClinical Neurology-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusSURVIVAL-
dc.subject.keywordPlusPROGRESSION-
dc.subject.keywordPlusDIAGNOSIS-
dc.subject.keywordPlusURATE-
dc.subject.keywordPlusALS-
dc.subject.keywordAuthoramyotrophic lateral sclerosis-
dc.subject.keywordAuthoruric acid-
dc.subject.keywordAuthorsurvival-
dc.subject.keywordAuthoroxidative stress-
dc.subject.keywordAuthorprognosis-
dc.identifier.urlhttps://www.thejcn.com/DOIx.php?id=10.3988/jcn.2015.11.4.376-
Files in This Item
Appears in
Collections
서울 의과대학 > 서울 신경과학교실 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Oh, Ki Wook photo

Oh, Ki Wook
COLLEGE OF MEDICINE (DEPARTMENT OF NEUROLOGY)
Read more

Altmetrics

Total Views & Downloads

BROWSE