UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1
DC Field | Value | Language |
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dc.contributor.author | Choi, Hee-Joo | - |
dc.contributor.author | Park, Ji-Hye | - |
dc.contributor.author | Park, Mikyung | - |
dc.contributor.author | Won, Hee-Young | - |
dc.contributor.author | Joo, Hyeong-seok | - |
dc.contributor.author | Lee, Chang Hoon | - |
dc.contributor.author | Lee, Jeong-Yeon | - |
dc.contributor.author | Kong, Gu | - |
dc.date.accessioned | 2022-07-15T20:51:40Z | - |
dc.date.available | 2022-07-15T20:51:40Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2015-10 | - |
dc.identifier.issn | 1469-221X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156250 | - |
dc.description.abstract | The histone H3K27 demethylase, UTX, is a known component of the H3K4 methyltransferase MLL complex, but its functional association with H3K4 methylation in human cancers remains largely unknown. Here we demonstrate that UTX loss induces epithelial-mesenchymal transition (EMT)-mediated breast cancer stem cell (CSC) properties by increasing the expression of the SNAIL, ZEB1 and ZEB2 EMT transcription factors (EMT-TFs) and of the transcriptional repressor CDH1. UTX facilitates the epigenetic silencing of EMT-TFs by inducing competition between MLL4 and the H3K4 demethylase LSD1. EMT-TF promoters are occupied by c-Myc and MLL4, and UTX recognizes these proteins, interrupting their transcriptional activation function. UTX decreases H3K4me2 and H3 acetylation at these promoters by forming a transcriptional repressive complex with LSD1, HDAC1 and DNMT1. Taken together, our findings indicate that UTX is a prominent tumour suppressor that functions as a negative regulator of EMT-induced CSC-like properties by epigenetically repressing EMT-TFs. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kong, Gu | - |
dc.identifier.doi | 10.15252/embr.201540244 | - |
dc.identifier.scopusid | 2-s2.0-84942817510 | - |
dc.identifier.wosid | 000362558100010 | - |
dc.identifier.bibliographicCitation | EMBO REPORTS, v.16, no.10, pp.1288 - 1298 | - |
dc.relation.isPartOf | EMBO REPORTS | - |
dc.citation.title | EMBO REPORTS | - |
dc.citation.volume | 16 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1288 | - |
dc.citation.endPage | 1298 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | ACUTE LYMPHOBLASTIC-LEUKEMIA | - |
dc.subject.keywordPlus | HISTONE DEMETHYLASE UTX | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | E-CADHERIN | - |
dc.subject.keywordPlus | LYSINE 27 | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | SNAIL | - |
dc.subject.keywordPlus | SUPPRESSOR | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | breast CSC | - |
dc.subject.keywordAuthor | EMT | - |
dc.subject.keywordAuthor | UTX | - |
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