Exercise training attenuates age-dependent elevation of angiotensin II type 1 receptor and Nox2 signaling in the rat heart
DC Field | Value | Language |
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dc.contributor.author | Lee, Yang | - |
dc.contributor.author | Kwak, Hyo-Bum | - |
dc.contributor.author | Hord, Jeff | - |
dc.contributor.author | Kim, Jong-Hee | - |
dc.contributor.author | Lawler, John M. | - |
dc.date.accessioned | 2022-07-15T20:52:25Z | - |
dc.date.available | 2022-07-15T20:52:25Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2015-10 | - |
dc.identifier.issn | 0531-5565 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156258 | - |
dc.description.abstract | Fibrosis of the aging heart impedes cardiac function and increases the risk of arrhythmias and heart disease. Previously, we demonstrated that exercise-induced reduction of collagen I in the aging heart was linked to a suppression of oxidative stress and transforming growth factor-beta (TGF-beta). The renin-angiotensin II system (RAS) increases oxidative stress via NADPH oxidase-2 (Nox2) and thus elevates TGF-beta and collagen accumulation. Therefore, we tested the hypothesis that exercise training would alleviate age-related upregulation of the angiotensin II receptor I (AT1R) and NADPH oxidase-2 (Nox2), concomitant with suppression of TGF-beta and fibrosis. Young (3 months, n = 20) and old (31 months, n = 20) Fischer 344 x Brown Norway F1 (FBNF1) hybrid rats were assigned into sedentary and exercise groups, with exercise training rats training on a treadmill 45 min/day, 5 days/week for the next 12 weeks. Exercise training mitigated age-related upregulation of AT1R, Nox2 activity, and Nox2 subunits gp91phox and p47phox. Exercise training also attenuated TGF-beta positive staining and downstream effectors of fibrosis in the aging heart: connective tissue growth factor, phosphorylation of Smad2 at Ser423, myofibroblast proliferation, and collagen I-positive staining. Our results are consistent with the hypothesis that exercise training protects against age-dependent cardiac fibrosis by suppressing AT1R and Nox2 as part of a RAS-Nox2-TGF-beta pathway. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Exercise training attenuates age-dependent elevation of angiotensin II type 1 receptor and Nox2 signaling in the rat heart | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong-Hee | - |
dc.identifier.doi | 10.1016/j.exger.2015.07.016 | - |
dc.identifier.scopusid | 2-s2.0-84943228218 | - |
dc.identifier.wosid | 000364252500024 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL GERONTOLOGY, v.70, pp.163 - 173 | - |
dc.relation.isPartOf | EXPERIMENTAL GERONTOLOGY | - |
dc.citation.title | EXPERIMENTAL GERONTOLOGY | - |
dc.citation.volume | 70 | - |
dc.citation.startPage | 163 | - |
dc.citation.endPage | 173 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Geriatrics & Gerontology | - |
dc.relation.journalWebOfScienceCategory | Geriatrics & Gerontology | - |
dc.subject.keywordPlus | INDUCED CARDIAC-HYPERTROPHY | - |
dc.subject.keywordPlus | NADPH OXIDASE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | NAD(P)H OXIDASE | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordAuthor | Aging | - |
dc.subject.keywordAuthor | Heart | - |
dc.subject.keywordAuthor | Angiotensin II receptor 1 | - |
dc.subject.keywordAuthor | NADPH oxidase | - |
dc.subject.keywordAuthor | TGF-beta | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0531556515300231?via%3Dihub | - |
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