Deferoxamine Improves Alveolar and Pulmonary Vascular Development by Upregulating Hypoxia-inducible Factor-1 alpha in a Rat Model of Bronchopulmonary Dysplasia
DC Field | Value | Language |
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dc.contributor.author | Choi, Chang Won | - |
dc.contributor.author | Lee, Juyoung | - |
dc.contributor.author | Lee, Hyun Ju | - |
dc.contributor.author | Park, Hyoung-Sook | - |
dc.contributor.author | Chun, Yang-Sook | - |
dc.contributor.author | Kim, Beyong Il | - |
dc.date.accessioned | 2022-07-15T21:08:41Z | - |
dc.date.available | 2022-07-15T21:08:41Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2015-09 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156452 | - |
dc.description.abstract | Fetal lung development normally occurs in a hypoxic environment. Hypoxia-inducible factor (HIF)-1 alpha is robustly induced under hypoxia and transactivates many genes that are essential for fetal development. Most preterm infants are prematurely exposed to hyperoxia, which can halt hypoxia-driven lung maturation. We were to investigate whether the HIF-1 alpha inducer, deferoxamine (DFX) can improve alveolarization in a rat model of bronchopulmonary dysplasia (BPD). A rat model of BPD was produced by intra-amniotic lipopolysaccharide (LPS) administration and postnatal hyperoxia (85% for 7 days), and DFX (150 mg/kg/d) or vehicle was administered to rat pups intraperitoneally for 14 days. On day 14, the rat pups were sacrificed and their lungs were removed and examined. A parallel in vitro study was performed with a human small airway epithelial cell line to test whether DFX induces the expression of HIF-1 alpha and its target genes. Alveolarization and pulmonary vascular development were impaired in rats with BPD. However, DFX significantly ameliorated these effects. Immunohistochemical analysis showed that HIF-1 alpha was significantly upregulated in the lungs of BPD rats treated with DFX. DFX was also found to induce HIF-1 alpha in human small airway epithelial cells and to promote the expression of HIF-1 alpha target genes. Our data suggest that DFX induces and activates HIF-1 alpha, thereby improving alveolarization and vascular distribution in the lungs of rats with BPD. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.title | Deferoxamine Improves Alveolar and Pulmonary Vascular Development by Upregulating Hypoxia-inducible Factor-1 alpha in a Rat Model of Bronchopulmonary Dysplasia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Ju | - |
dc.identifier.doi | 10.3346/jkms.2015.30.9.1295 | - |
dc.identifier.scopusid | 2-s2.0-84945943556 | - |
dc.identifier.wosid | 000364208300013 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.30, no.9, pp.1295 - 1301 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 30 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1295 | - |
dc.citation.endPage | 1301 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002028745 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | CHRONIC LUNG-DISEASE | - |
dc.subject.keywordPlus | PRIMATE LUNG | - |
dc.subject.keywordPlus | OXYGEN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | MORPHOGENESIS | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | HYPEROXIA | - |
dc.subject.keywordAuthor | Alveolarization | - |
dc.subject.keywordAuthor | Bronchopulmonary Dysplasia | - |
dc.subject.keywordAuthor | Deferoxamine | - |
dc.subject.keywordAuthor | Hypoxia-Inducible Factor | - |
dc.identifier.url | https://jkms.org/DOIx.php?id=10.3346/jkms.2015.30.9.1295 | - |
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