AROS Is a Significant Biomarker for Tumor Aggressiveness in Non-cirrhotic Hepatocellular Carcinoma
DC Field | Value | Language |
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dc.contributor.author | Kwon, Jung-Hee | - |
dc.contributor.author | Ahn, Keun Soo | - |
dc.contributor.author | Moon, Young Ho | - |
dc.contributor.author | Park, Jin Young | - |
dc.contributor.author | Wang, Hee Jung | - |
dc.contributor.author | Choi, Kwan Yong | - |
dc.contributor.author | Kim, Gundo | - |
dc.contributor.author | Joh, Jae Won | - |
dc.contributor.author | Lee, Kyeong Geun | - |
dc.contributor.author | Kang, Koo Jeong | - |
dc.date.accessioned | 2022-07-15T21:08:46Z | - |
dc.date.available | 2022-07-15T21:08:46Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2015-09 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156453 | - |
dc.description.abstract | Despite a low risk of liver failure and preserved liver function, non-cirrhotic hepatocellular carcinoma (HCC) has a poor prognosis. In the current study, we evaluated an active regulator of SIRT1 (AROS) as a prognostic biomarker in non-cirrhotic HCC. mRNA levels of AROS were measured in tumor and non-tumor tissues obtained from 283 non-cirrhotic HCC patients. AROS expression was exclusively up-regulated in recurrent tissues from the non-cirrhotic HCC patients (P = 0.015) and also in tumor tissues irrespective of tumor stage (P < 0.001) or BCLC stage (P < 0.001). High mRNA levels of AROS were statistically significantly associated with tumor stage (P < 0.001), BCLC stage (P = 0.007), alpha fetoprotein (AFP) level (P = 0.013), microvascular invasion (P = 0.001), tumor size (P = 0.036), and portal vein invasion (P = 0.005). Kaplan-Meir curve analysis demonstrated that HCC patients with higher AROS levels had shorter disease-free survival (DFS) in both the short-term (P < 0.001) and long-term (P = 0.005) compared to those with low AROS. Cox regression analysis demonstrated that AROS is a significant predictor for DFS along with large tumor size, tumor multiplicity, vascular invasion, and poor tumor differentiation, which are the known prognostic factors. In conclusion, AROS is a significant biomarker for tumor aggressiveness in non-cirrhotic hepatocellular carcinoma. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.title | AROS Is a Significant Biomarker for Tumor Aggressiveness in Non-cirrhotic Hepatocellular Carcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kyeong Geun | - |
dc.identifier.doi | 10.3346/jkms.2015.30.9.1253 | - |
dc.identifier.scopusid | 2-s2.0-84945928478 | - |
dc.identifier.wosid | 000364208300007 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.30, no.9, pp.1253 - 1259 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 30 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1253 | - |
dc.citation.endPage | 1259 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002028734 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | LONG-TERM SURVIVAL | - |
dc.subject.keywordPlus | RIBOSOME BIOGENESIS | - |
dc.subject.keywordPlus | PROGNOSTIC-FACTORS | - |
dc.subject.keywordPlus | HEPATIC RESECTION | - |
dc.subject.keywordPlus | ACTIVE REGULATOR | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | SIRT1 | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CIRRHOSIS | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordAuthor | Carcinoma | - |
dc.subject.keywordAuthor | Hepatocellular | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Biological Markers | - |
dc.identifier.url | https://jkms.org/DOIx.php?id=10.3346/jkms.2015.30.9.1253 | - |
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