Efficacy of a Once-Monthly Pill Containing Ibandronate and Cholecalciferol on the Levels of 25-Hydroxyvitamin D and Bone Markers in Postmenopausal Women with Osteoporosis
DC Field | Value | Language |
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dc.contributor.author | Cho, In-Jin | - |
dc.contributor.author | Chung, Ho-Yeon | - |
dc.contributor.author | Kim, Sung-Woon | - |
dc.contributor.author | Lee, Jae-Won | - |
dc.contributor.author | Lee, Tae-Won | - |
dc.contributor.author | Kim, Hye-Soon | - |
dc.contributor.author | Kim, Sin-Gon | - |
dc.contributor.author | Choi, Han Seok | - |
dc.contributor.author | Choi, Sung-Hee | - |
dc.contributor.author | Shin, Chan Soo | - |
dc.contributor.author | Oh, Ki-Won | - |
dc.contributor.author | Min, Yong-Ki | - |
dc.contributor.author | Koh, Jung-Min | - |
dc.contributor.author | Rhee, Yumie | - |
dc.contributor.author | Byun, Dong-Won | - |
dc.contributor.author | Chung, Yoon-Sok | - |
dc.contributor.author | Park, Jeong Hyun | - |
dc.contributor.author | Chung, Dong Jin | - |
dc.contributor.author | Shong, Minho | - |
dc.contributor.author | Hong, Eun-Gyoung | - |
dc.contributor.author | Lee, Chang Beom | - |
dc.contributor.author | Baek, Ki Hyun | - |
dc.contributor.author | Kang, Moo-Il | - |
dc.date.accessioned | 2022-07-15T21:09:17Z | - |
dc.date.available | 2022-07-15T21:09:17Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2015-09 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156458 | - |
dc.description.abstract | Background: The present study evaluated the efficacy of a combination of ibandronate and cholecalciferol on the restoration of the levels of 25-hydroxyvitamin D (25[OH] D) and various bone markers in postmenopausal women with osteoporosis. Methods: This was a randomized, double-blind, active-controlled, prospective 16-week clinical trial conducted in 20 different hospitals. A total of 201 postmenopausal women with osteoporosis were assigned randomly to one of two groups: the IBN group, which received a once-monthly pill containing 150 mg ibandronate (n=99), or the IBN+ group, which received a once-monthly pill containing 150 mg ibandronate and 24,000 IU cholecalciferol (n=102). Serum levels of 25(OH) D, parathyroid hormone (PTH), and various bone markers were assessed at baseline and at the end of a 16-week treatment period. Results: After 16 weeks of treatment, the mean serum levels of 25(OH) D significantly increased from 21.0 to 25.3 ng/mL in the IBN+ group but significantly decreased from 20.6 to 17.4 ng/mL in the IBN group. Additionally, both groups exhibited significant increases in mean serum levels of PTH but significant decreases in serum levels of bone-specific alkaline phosphatase and C-telopeptide of type 1 collagen (CTX) at 16 weeks; no significant differences were observed between the groups. However, in subjects with a vitamin D deficiency, IBN+ treatment resulted in a significant decrease in serum CTX levels compared with IBN treatment. Conclusion: The present findings demonstrate that a once-monthly pill containing ibandronate and cholecalciferol may be useful for the amelioration of vitamin D deficiency in patients with postmenopausal osteoporosis. Moreover, this treatment combination effectively decreased serum levels of resorption markers, especially in subjects with a vitamin D deficiency, over the 16-week treatment period. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ENDOCRINE SOC | - |
dc.title | Efficacy of a Once-Monthly Pill Containing Ibandronate and Cholecalciferol on the Levels of 25-Hydroxyvitamin D and Bone Markers in Postmenopausal Women with Osteoporosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Chang Beom | - |
dc.identifier.doi | 10.3803/EnM.2015.30.3.272 | - |
dc.identifier.scopusid | 2-s2.0-84955447019 | - |
dc.identifier.bibliographicCitation | ENDOCRINOLOGY AND METABOLISM, v.30, no.3, pp.272 - 279 | - |
dc.relation.isPartOf | ENDOCRINOLOGY AND METABOLISM | - |
dc.citation.title | ENDOCRINOLOGY AND METABOLISM | - |
dc.citation.volume | 30 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 272 | - |
dc.citation.endPage | 279 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002031555 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Ibandronate | - |
dc.subject.keywordAuthor | Cholecalciferol | - |
dc.subject.keywordAuthor | 25-hydroxyvitamin D | - |
dc.subject.keywordAuthor | Bone markers | - |
dc.identifier.url | https://www.e-enm.org/journal/view.php?doi=10.3803/EnM.2015.30.3.272 | - |
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