Optimal combination treatment and vascular outcomes in recent ischemic stroke patients by premorbid risk level.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jong Ho | - |
dc.contributor.author | Ovbiagele, Bruce | - |
dc.date.accessioned | 2022-07-15T21:28:26Z | - |
dc.date.available | 2022-07-15T21:28:26Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2015-08 | - |
dc.identifier.issn | 0022-510X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156560 | - |
dc.description.abstract | Background Optimal combination of secondary stroke prevention treatment including antihypertensives, antithrombotic agents, and lipid modifiers is associated with reduced recurrent vascular risk including stroke. It is unclear whether optimal combination treatment has a differential impact on stroke patients based on level of vascular risk. Methods We analyzed a clinical trial dataset comprising 3680 recent non-cardioembolic stroke patients aged ≥ 35 years and followed for 2 years. Patients were categorized by appropriateness levels 0 to III depending on the number of the drugs prescribed divided by the number of drugs potentially indicated for each patient (0 = none of the indicated medications prescribed and III = all indicated medications prescribed [optimal combination treatment]). High-risk was defined as having a history of stroke or coronary heart disease (CHD) prior to the index stroke event. Independent associations of medication appropriateness level with a major vascular event (stroke, CHD, or vascular death), ischemic stroke, and all-cause death were analyzed. Results Compared with level 0, for major vascular events, the HR of level III in the low-risk group was 0.51 (95% CI: 0.20-1.28) and 0.32 (0.14-0.70) in the high-risk group; for stroke, the HR of level III in the low-risk group was 0.54 (0.16-1.77) and 0.25 (0.08-0.85) in the high-risk group; and for all-cause death, the HR of level III in the low-risk group was 0.66 (0.09-5.00) and 0.22 (0.06-0.78) in the high-risk group. Conclusion Optimal combination treatment is related to a significantly lower risk of future vascular events and death among high-risk patients after a recent non-cardioembolic stroke. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Optimal combination treatment and vascular outcomes in recent ischemic stroke patients by premorbid risk level. | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Jong Ho | - |
dc.identifier.doi | 10.1016/j.jns.2015.05.028 | - |
dc.identifier.scopusid | 2-s2.0-84937526028 | - |
dc.identifier.wosid | 000358388800017 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE NEUROLOGICAL SCIENCES, v.355, no.1-2, pp.90 - 93 | - |
dc.relation.isPartOf | JOURNAL OF THE NEUROLOGICAL SCIENCES | - |
dc.citation.title | JOURNAL OF THE NEUROLOGICAL SCIENCES | - |
dc.citation.volume | 355 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 90 | - |
dc.citation.endPage | 93 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Death | - |
dc.subject.keywordAuthor | Drug | - |
dc.subject.keywordAuthor | High-risk | - |
dc.subject.keywordAuthor | Secondary prevention | - |
dc.subject.keywordAuthor | Stroke | - |
dc.subject.keywordAuthor | Vascular events | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0022510X1500310X?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.