Red ginseng extract blocks histamine-dependent itch by inhibition of H1R/TRPV1 pathway in sensory neurons
DC Field | Value | Language |
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dc.contributor.author | Jang, Yongwoo | - |
dc.contributor.author | Lee, Wook-Joo | - |
dc.contributor.author | Hong, Gyu-Sang | - |
dc.contributor.author | Shim, Won-Sik | - |
dc.date.accessioned | 2022-07-15T21:55:53Z | - |
dc.date.available | 2022-07-15T21:55:53Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2015-07 | - |
dc.identifier.issn | 1226-8453 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156764 | - |
dc.description.abstract | Background: Korean Red Ginseng-a steamed root of Panax ginseng Meyer-has long been used as a traditional medicine in Asian countries. Its antipruritic effect was recently found, but no molecular mechanisms were revealed. Thus, the current study focused on determining the underlying molecular mechanism of Korean Red Ginseng extract (RGE) against histamine-induced itch at the peripheral sensory neuronal level. Methods: To examine the antipruritic effect of RGE, we performed in vivo scratching behavior test in mice, as well as in vitro calcium imaging and whole-cell patch clamp experiments to elucidate underlying molecular mechanisms. Results: The results of our in vivo study confirmed that RGE indeed has an antipruritic effect on histamine-induced scratching in mice. In addition, RGE showed a significant inhibitory effect on histamine-induced responses in primary cultures of mouse dorsal root ganglia, suggesting that RGE has a direct inhibitory effect on sensory neuronal level. Results of further experiments showed that RGE inhibits histamine-induced responses on cells expressing both histamine receptor subtype I and TRPV1 ion channel, indicating that RGE blocks the histamine receptor type 1/TRPV1 pathway in sensory neurons, which is responsible for histamine-dependent itch sensation. Conclusion: The current study found for the first time that RGE effectively blocks histamine-induced itch in peripheral sensory neurons. We believe that the current results will provide an insight on itch transmission and will be helpful in understanding how RGE exerts its antipruritic effects. Results: The results of our in vivo study confirmed that RGE indeed has an antipruritic effect on histamine-induced scratching in mice. In addition, RGE showed a significant inhibitory effect on histamine-induced responses in primary cultures of mouse dorsal root ganglia, suggesting that RGE has a direct inhibitory effect on sensory neuronal level. Results of further experiments showed that RGE inhibits histamine-induced responses on cells expressing both histamine receptor subtype I and TRPV1 ion channel, indicating that RGE blocks the histamine receptor type 1/TRPV1 pathway in sensory neurons, which is responsible for histamine-dependent itch sensation. Conclusion: The current study found for the first time that RGE effectively blocks histamine-induced itch in peripheral sensory neurons. We believe that the current results will provide an insight on itch transmission and will be helpful in understanding how RGE exerts its antipruritic effects. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 고려인삼학회 | - |
dc.title | Red ginseng extract blocks histamine-dependent itch by inhibition of H1R/TRPV1 pathway in sensory neurons | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jang, Yongwoo | - |
dc.identifier.doi | 10.1016/j.jgr.2015.01.004 | - |
dc.identifier.scopusid | 2-s2.0-84936847678 | - |
dc.identifier.wosid | 000358550000010 | - |
dc.identifier.bibliographicCitation | Journal of Ginseng Research, v.39, no.3, pp.257 - 264 | - |
dc.relation.isPartOf | Journal of Ginseng Research | - |
dc.citation.title | Journal of Ginseng Research | - |
dc.citation.volume | 39 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 257 | - |
dc.citation.endPage | 264 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.identifier.kciid | ART002012744 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.subject.keywordPlus | ATOPIC-DERMATITIS | - |
dc.subject.keywordPlus | PANAX-GINSENG | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | METABOLITE | - |
dc.subject.keywordPlus | SENSATION | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | H1R | - |
dc.subject.keywordAuthor | histamine | - |
dc.subject.keywordAuthor | itch | - |
dc.subject.keywordAuthor | Korean Red Ginseng extract | - |
dc.subject.keywordAuthor | TRPV1 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S122684531500007X?via%3Dihub | - |
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