Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Dexamethasone-Conjugated Polyamidoamine Dendrimer for Delivery of the Heme Oxygenase-1 Gene into the Ischemic Brain
Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Jeon, Pureum | - |
| dc.contributor.author | Choi, Manbok | - |
| dc.contributor.author | Oh, Jungju | - |
| dc.contributor.author | Lee, Minhyung | - |
| dc.date.accessioned | 2022-07-15T22:04:21Z | - |
| dc.date.available | 2022-07-15T22:04:21Z | - |
| dc.date.issued | 2015-07 | - |
| dc.identifier.issn | 1616-5187 | - |
| dc.identifier.issn | 1616-5195 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156861 | - |
| dc.description.abstract | Heme oxygenase-1 (HO-1) has anti-apoptotic and anti-inflammatory effects. In this study, the HO-1 gene was delivered into the brain using dexamethasone-conjugated polyamidoamine generation 2 (PAMAMG2-Dexa) for the treatment of ischemic stroke. PAMAM G2-Dexa formed stable complexes with plasmid DNA (pDNA). The pDNA delivery efficiency of PAMAM G2-Dexa was higher than that of polyethylenimine (PEI25k, 25 kDa), dexamethasone-conjugated PEI (PEI-Dexa), and PAMAM G2 in Neuro2A cells. Therapeutic effect of PAMAM G2-Dexa/pHO-1 complexes was evaluated in a stroke animal model. PAMAM G2-Dexa delivered pHO-1 more efficiently into the ischemic brain than PEI25k and PEI-Dexa with higher therapeutic effect. Therefore, PAMAMG2-Dexa/pHO-1 complexes may be useful for ischemic stroke gene therapy. | - |
| dc.format.extent | 8 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | John Wiley & Sons Ltd. | - |
| dc.title | Dexamethasone-Conjugated Polyamidoamine Dendrimer for Delivery of the Heme Oxygenase-1 Gene into the Ischemic Brain | - |
| dc.type | Article | - |
| dc.publisher.location | 독일 | - |
| dc.identifier.doi | 10.1002/mabi.201500058 | - |
| dc.identifier.scopusid | 2-s2.0-84948578565 | - |
| dc.identifier.wosid | 000358015600012 | - |
| dc.identifier.bibliographicCitation | Macromolecular Bioscience, v.15, no.7, pp 1021 - 1028 | - |
| dc.citation.title | Macromolecular Bioscience | - |
| dc.citation.volume | 15 | - |
| dc.citation.number | 7 | - |
| dc.citation.startPage | 1021 | - |
| dc.citation.endPage | 1028 | - |
| dc.type.docType | Article | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | sci | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
| dc.relation.journalResearchArea | Materials Science | - |
| dc.relation.journalResearchArea | Polymer Science | - |
| dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
| dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
| dc.relation.journalWebOfScienceCategory | Polymer Science | - |
| dc.subject.keywordPlus | POLYETHYLENIMINE | - |
| dc.subject.keywordPlus | CARRIER | - |
| dc.subject.keywordAuthor | dexamethasone | - |
| dc.subject.keywordAuthor | gene therapy | - |
| dc.subject.keywordAuthor | heme oxygenase-1 | - |
| dc.subject.keywordAuthor | polyamidoamine | - |
| dc.subject.keywordAuthor | stroke | - |
| dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/mabi.201500058 | - |
- Files in This Item
- Go to Link
- Appears in
Collections - 서울 공과대학 > 서울 생명공학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Lee, Min hyung
- COLLEGE OF ENGINEERING (DEPARTMENT OF BIOENGINEERING)