A randomized controlled trial of the effect of preoperative dexmedetomidine on the half maximal effective concentration of propofol for successful i-gel insertion without muscle relaxants.
DC Field | Value | Language |
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dc.contributor.author | Jang, Young-Eun | - |
dc.contributor.author | Kim, Yong-Chul | - |
dc.contributor.author | Yoon, Hyun-Kyu | - |
dc.contributor.author | Jeon, Young-Tae | - |
dc.contributor.author | Hwang, Jung-Won | - |
dc.contributor.author | Kim, Eu gene | - |
dc.contributor.author | Park, Hee-Pyoung | - |
dc.date.accessioned | 2022-07-15T22:14:01Z | - |
dc.date.available | 2022-07-15T22:14:01Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 0913-8668 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156961 | - |
dc.description.abstract | Dexmedetomidine is a useful anesthetic adjuvant for general anesthesia. We determined whether preoperative dexmedetomidine administration could reduce the half maximal effective concentration (EC50) of propofol for successful i-gel insertion without muscle relaxants. Thirty-seven patients were randomly allocated to one of two groups. In the dexmedetomidine group (n = 19), dexmedetomidine (1 A mu g/kg) was loaded for 10 min preoperatively. In the control group (n = 20), the same volume of 0.9 % normal saline was administered in the same manner. The EC50 of propofol for successful i-gel insertion was determined using Dixon's up-and-down method. The EC50 of propofol was calculated as the midpoint concentration after at least six crossover points had been obtained. For successful i-gel insertion, all of the following four factors were required-(1) no major movement of the body within 1 min of insertion, (2) no significant resistance to mouth opening, (3) cough a parts per thousand currency sign2, and (4) visible square wave capnogram without air leakage at a peak airway pressure of < 10 cmH(2)O. Mean blood pressure (MBP) and heart rate (HR) were monitored during the peri-insertion period of i-gel. The EC50 of propofol for successful i-gel insertion was 3.18 mu g/mL in the dexmedetomidine group and 6.75 mu g/mL in the control group (p < 0.001). The incidence of hypotension (MBP < 80 % of the baseline) during the peri-insertion period of i-gel was higher in the control group (p = 0.001), whereas the incidence of bradycardia (HR < 80 % of the baseline) was higher in the dexmedetomidine group (p = 0.001). Preoperative dexmedetomidine reduced the EC50 of propofol for successful i-gel insertion without muscle relaxants. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER JAPAN KK | - |
dc.title | A randomized controlled trial of the effect of preoperative dexmedetomidine on the half maximal effective concentration of propofol for successful i-gel insertion without muscle relaxants. | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Eu gene | - |
dc.identifier.doi | 10.1007/s00540-014-1949-9 | - |
dc.identifier.scopusid | 2-s2.0-84934435447 | - |
dc.identifier.wosid | 000357281100004 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ANESTHESIA, v.29, no.3, pp.338 - 345 | - |
dc.relation.isPartOf | JOURNAL OF ANESTHESIA | - |
dc.citation.title | JOURNAL OF ANESTHESIA | - |
dc.citation.volume | 29 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 338 | - |
dc.citation.endPage | 345 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Anesthesiology | - |
dc.relation.journalWebOfScienceCategory | Anesthesiology | - |
dc.subject.keywordPlus | LARYNGEAL MASK AIRWAY | - |
dc.subject.keywordPlus | INDUCED RESPIRATORY DEPRESSION | - |
dc.subject.keywordPlus | SINGLE-DOSE DEXMEDETOMIDINE | - |
dc.subject.keywordPlus | TARGET-CONTROLLED INFUSION | - |
dc.subject.keywordPlus | FIBEROPTIC INTUBATION | - |
dc.subject.keywordPlus | SUPRAGLOTTIC AIRWAY | - |
dc.subject.keywordPlus | CARDIOPULMONARY-RESUSCITATION | - |
dc.subject.keywordPlus | HEMODYNAMIC-RESPONSES | - |
dc.subject.keywordPlus | ANESTHESIA | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordAuthor | Dexmedetomidine | - |
dc.subject.keywordAuthor | i-gel | - |
dc.subject.keywordAuthor | Propofol | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s00540-014-1949-9?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot | - |
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