Evaluation of Early-Stage Hepatocellular Carcinoma by Magnetic Resonance Imaging With Gadoxetic Acid Detects Additional Lesions and Increases Overall Survival
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyung-Don | - |
dc.contributor.author | Lim, Young-Suk | - |
dc.contributor.author | Han, Seungbong | - |
dc.contributor.author | An, Ji hyun | - |
dc.contributor.author | Kim, Gi-Ae | - |
dc.contributor.author | Kim, So Yeon | - |
dc.contributor.author | Lee, So Jung | - |
dc.contributor.author | Won, Hyung Jin | - |
dc.contributor.author | Byun, Jae Ho | - |
dc.date.accessioned | 2022-07-15T22:14:08Z | - |
dc.date.available | 2022-07-15T22:14:08Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 0016-5085 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/156962 | - |
dc.description.abstract | Background & Aims Hepatocellular carcinoma (HCC) has a high rate of intrahepatic recurrence after curative treatment, possibly because metastases are not always identified before treatment. Magnetic resonance (MR) imaging with a liver-specific contrast agent, gadoxetic acid, can detect small HCCs with high levels of sensitivity. We investigated whether MR imaging with gadoxetic acid increases overall and recurrence-free survival of patients initially assessed by computed tomography (CT). Methods We performed a retrospective study of data from 700 patients diagnosed with a single-nodular HCC by dynamic 4-phase CT in Seoul, Korea, from January 2009 through December 2010. Of these patients, 323 underwent additional evaluation with gadoxetic acid-enhanced MR imaging (CT+MR group). The 377 patients who did not undergo MR imaging analysis are referred to as the CT group. Results The CT and CT+MR groups were comparable in most baseline characteristics (Child-Pugh class A, 93.1% vs 94.7%; and median size of the primary HCCs, 2.8 vs 2.6 cm, respectively). Seventy-four additional HCC nodules were detected in 53 (16.4%) of the patients who underwent MR evaluation after CT (CT+MR group). These detections increased the Barcelona Clinic Liver Cancer stages for 43 patients (13.3%) and modified their treatment plans. On multivariable analyses, the CT+MR group had a significantly lower rate of HCC recurrence (hazard ratio [HR], 0.72; 95% confidence interval [CI], 0.54-0.96) and lower overall mortality (HR, 0.65; 95% CI, 0.44-0.96) than the CT group. In an analysis of 285 pairs of patients matched on the basis of the propensity score, the CT+MR group had significantly lower overall mortality (HR, 0.66; 95% CI, 0.44-0.99). Conclusions Among patients who underwent dynamic CT analysis of a single-nodular HCC, additional evaluation by MR imaging with gadoxetic acid led to the detection of additional HCC nodules in 16% of patients, reduced the risk of disease recurrence, and decreased overall mortality. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | - |
dc.title | Evaluation of Early-Stage Hepatocellular Carcinoma by Magnetic Resonance Imaging With Gadoxetic Acid Detects Additional Lesions and Increases Overall Survival | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | An, Ji hyun | - |
dc.identifier.doi | 10.1053/j.gastro.2015.02.051 | - |
dc.identifier.scopusid | 2-s2.0-84930038367 | - |
dc.identifier.wosid | 000355014700029 | - |
dc.identifier.bibliographicCitation | GASTROENTEROLOGY, v.148, no.7, pp.1371 - 1382 | - |
dc.relation.isPartOf | GASTROENTEROLOGY | - |
dc.citation.title | GASTROENTEROLOGY | - |
dc.citation.volume | 148 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1371 | - |
dc.citation.endPage | 1382 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | GD-EOB-DTPA | - |
dc.subject.keywordPlus | NONINVASIVE DIAGNOSTIC-CRITERIA | - |
dc.subject.keywordPlus | DISODIUM-ENHANCED MRI | - |
dc.subject.keywordPlus | INTRAHEPATIC RECURRENCE | - |
dc.subject.keywordPlus | PROTOCOL OPTIMIZATION | - |
dc.subject.keywordPlus | DYSPLASTIC NODULES | - |
dc.subject.keywordPlus | UNITED-STATES | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | SPIRAL CT | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordAuthor | BCLC | - |
dc.subject.keywordAuthor | Gadoxetic Acid | - |
dc.subject.keywordAuthor | Liver Cancer | - |
dc.subject.keywordAuthor | Combined Image Analyses | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0016508515003005?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.