Association between ADH1B and ADH1C polymorphisms and the risk of head and neck squamous cell carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ji, Yong Bae | - |
dc.contributor.author | Lee, Seung Hwan | - |
dc.contributor.author | Kim, Kyung Rae | - |
dc.contributor.author | Park, Chul Won | - |
dc.contributor.author | Song, Chang Myeon | - |
dc.contributor.author | Park, Byung Lae | - |
dc.contributor.author | Shin, Hyoung Doo | - |
dc.contributor.author | Tae, Kyung | - |
dc.date.accessioned | 2022-07-15T22:44:43Z | - |
dc.date.available | 2022-07-15T22:44:43Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 1010-4283 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/157146 | - |
dc.description.abstract | Alcohol consumption is one of the major risk factors for head and neck squamous cell carcinoma (HNSCC), and the alcohol dehydrogenase (ADH) family proteins are key enzymes in ethanol metabolism. We examined the associations between single nucleotide polymorphisms (SNPs) of ADH1B and ADH1C and the risk of HNSCC. We analyzed six SNPS of ADH1B, namely -992C > G, -957C > A, +3170A > G, +3377G > T, +3491G > A, and +13543A > G, and five SNPs of ADH1C, namely -1064C > T, -325G > C, +5702A > G, +7462T > C, and +13044A > G, in 260 Korean HNSCC patients and 330 controls, using single base extension and the TaqMan assay. The odds ratios (ORs) and 95 % confidence intervals (95 % CIs) of the CG and GG genotypes of ADH1B -992C > G, the AA genotype of -957C > A, the GG genotype of +3170A > G, the GA genotype of +3491G > A, and +13543A > G were 0.51 (0.32-0.82), 0.63 (0.42-0.94), 1.84 (1.13-2.99), 1.77 (1.15-2.73), 2.34 (1.44-3.79), and 2.21 (1.23-3.95), respectively. The ORs of ADH1C +13044A > G were 1.94 (1.01-3.71) and 1.97 (1.05-3.71) in the dominant and co-dominant models, respectively. The ORs of the GC genotype of ADH1C -325G > C and the AG genotype of +5702A > G were 2.52 (1.51-4.21) and 2.43 (1.36-4.32), respectively. ADH1B +3170A > G and ADH1C +13044A > G were in strong linkage disequilibrium with the other SNPs of ADH1B and ADH1C, respectively. There were gene-environment interactions between ADH1B +3170A > G and ADH1C +13044A > G and alcohol consumption and smoking. ADH1B +3170A > G and ADH1C +13044A > G SNPs are associated with an increased risk of HNSCC, and they could be used as biomarkers for the high-risk group of HNSCC in Koreans. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.title | Association between ADH1B and ADH1C polymorphisms and the risk of head and neck squamous cell carcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ji, Yong Bae | - |
dc.contributor.affiliatedAuthor | Lee, Seung Hwan | - |
dc.contributor.affiliatedAuthor | Song, Chang Myeon | - |
dc.contributor.affiliatedAuthor | Tae, Kyung | - |
dc.identifier.doi | 10.1007/s13277-015-3078-y | - |
dc.identifier.scopusid | 2-s2.0-84938994751 | - |
dc.identifier.wosid | 000359383700044 | - |
dc.identifier.bibliographicCitation | TUMOR BIOLOGY, v.36, no.6, pp.4387 - 4396 | - |
dc.relation.isPartOf | TUMOR BIOLOGY | - |
dc.citation.title | TUMOR BIOLOGY | - |
dc.citation.volume | 36 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 4387 | - |
dc.citation.endPage | 4396 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | GENE-ENVIRONMENT INTERACTIONS | - |
dc.subject.keywordPlus | LIVER ALCOHOL-DEHYDROGENASE | - |
dc.subject.keywordPlus | UPPER AERODIGESTIVE TRACT | - |
dc.subject.keywordPlus | CANCER-RISK | - |
dc.subject.keywordPlus | ALDEHYDE DEHYDROGENASE | - |
dc.subject.keywordPlus | ALCOHOL-DEHYDROGENASE-3 GENOTYPE | - |
dc.subject.keywordPlus | METABOLIZING ENZYMES | - |
dc.subject.keywordPlus | KOREAN POPULATION | - |
dc.subject.keywordPlus | ORAL CAVITY | - |
dc.subject.keywordPlus | ACETALDEHYDE | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | SNP | - |
dc.subject.keywordAuthor | ADH1B | - |
dc.subject.keywordAuthor | ADH1C | - |
dc.subject.keywordAuthor | Head and neck cancer | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.