Incidence of hepatocellular carcinoma after HBsAg seroclearance in chronic hepatitis B patients: A need for surveillance
DC Field | Value | Language |
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dc.contributor.author | Kim, Gi-Ae | - |
dc.contributor.author | Lee, Han Chu | - |
dc.contributor.author | Kim, Min-Ju | - |
dc.contributor.author | Ha, Yeonjung | - |
dc.contributor.author | Park, Eui Ju | - |
dc.contributor.author | An, Ji hyun | - |
dc.contributor.author | Lee, Danbi | - |
dc.contributor.author | Shim, Ju Hyun | - |
dc.contributor.author | Kim, Kang Mo | - |
dc.contributor.author | Lim, Young-Suk | - |
dc.date.accessioned | 2022-07-15T22:51:11Z | - |
dc.date.available | 2022-07-15T22:51:11Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 0168-8278 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/157225 | - |
dc.description.abstract | Background & Aims Little is known about whether surveillance for hepatocellular carcinoma (HCC) is worthwhile in chronic hepatitis B virus (HBV)-infected patients who have achieved HBsAg seroclearance. Methods A retrospective analysis of 829 patients (mean age: 52.3 years; 575 males; 98 with cirrhosis) achieving HBsAg seroclearance was performed at a tertiary hospital in Korea between 1997 and 2012. We evaluated incidence rates of HCC, and validated CU-HCC score based on data at the time of HBsAg seroclearance. Results During a follow-up of 3464 patient-years, 19 patients developed HCC (annual rate: 0.55%). Liver cirrhosis (hazard ratio [HR]: 10.80; 95% confidence interval [CI]: 4.25-27.43), male gender (HR: 8.96; 95% CI: 1.17-68.80), and age ≥50 years at the time of HBsAg seroclearance (HR: 12.14; 95% CI: 1.61-91.68) were independently associated with HCC. The estimated annual incidence of HCC was 2.85% and 0.29% in patients with and without cirrhosis, respectively. Among the non-cirrhotic patients, the annual rate of HCC was higher in the male patients than in the females (0.40% vs. 0%, respectively), and all the HCCs developed after age 50. The time-dependent area under the receiver operating characteristic curves for the CU-HCC score for 5 year and 10 year HCC prediction were 0.85 and 0.74, respectively. Conclusions HCC surveillance should be considered for cirrhotic patients and non-cirrhotic male patients over age 50, even after HBsAg seroclearance, especially those infected with HBV genotype C. HBsAg seroclearance at age ≥50 years was also an independent predictor for HCC. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Incidence of hepatocellular carcinoma after HBsAg seroclearance in chronic hepatitis B patients: A need for surveillance | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | An, Ji hyun | - |
dc.identifier.doi | 10.1016/j.jhep.2014.11.031 | - |
dc.identifier.scopusid | 2-s2.0-84927800027 | - |
dc.identifier.wosid | 000353124800018 | - |
dc.identifier.bibliographicCitation | JOURNAL OF HEPATOLOGY, v.62, no.5, pp.1092 - 1099 | - |
dc.relation.isPartOf | JOURNAL OF HEPATOLOGY | - |
dc.citation.title | JOURNAL OF HEPATOLOGY | - |
dc.citation.volume | 62 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1092 | - |
dc.citation.endPage | 1099 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | SURFACE-ANTIGEN SEROCLEARANCE | - |
dc.subject.keywordPlus | CHRONIC HBV INFECTION | - |
dc.subject.keywordPlus | TERM-FOLLOW-UP | - |
dc.subject.keywordPlus | HIGH-RATES | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | CIRRHOSIS | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordAuthor | HBV | - |
dc.subject.keywordAuthor | Liver cancer | - |
dc.subject.keywordAuthor | Survival | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0168827814008800?via%3Dihub | - |
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