Histologic and metabolic derangement in high-fat, high-fructose, and combination diet animal models
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jai Sun | - |
dc.contributor.author | Jun, Dae Won | - |
dc.contributor.author | Kim, Eun Kyung | - |
dc.contributor.author | Jeon, Hye Joon | - |
dc.contributor.author | Nam, Ho Hyun | - |
dc.contributor.author | Saeed, Waqar Khalid | - |
dc.date.accessioned | 2022-07-15T22:54:13Z | - |
dc.date.available | 2022-07-15T22:54:13Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 2356-6140 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/157269 | - |
dc.description.abstract | Background. We used high-fat (HF), high-fructose (HFr), and combination diets to create a dietary animal model of nonalcoholic fatty liver disease (NAFLD). Comparison of both clinical phenotypes has not been well defined. The purpose of this study was to compare histologic and metabolic characteristics between diets in an animal model of NAFLD. Methods. NAFLD was induced in rats by feeding them HF, HFr, and combination (HF + HFr) diets for 20 weeks. The degree of intrahepatic fat accumulation, inflammation, and oxidative stress was evaluated. Metabolic derangements were assessed by the oral glucose tolerance test and the intrahepatic insulin signal pathway. Results. Body weight gain and intrahepatic fat accumulation were more prominent in the HF feeding group than in the HFr group. The expressions of NOX-4 and TLR-4 were higher in the HF and HFr combination groups than in the HF-only group. Other intrahepatic inflammatory markers, MCP-1, TNF-α, and endoplasmic reticulum stress markers, were the highest in the HF + HFr combination group. Although intrahepatic fat deposition was less prominent in the HFr diet model, intrahepatic inflammation was noted. Conclusions. Intrahepatic inflammation and metabolic derangements were more prominent in the HF and HFr combination model than in the HF monodiet model. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Hindawi Publishing Corporation | - |
dc.title | Histologic and metabolic derangement in high-fat, high-fructose, and combination diet animal models | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jun, Dae Won | - |
dc.identifier.doi | 10.1155/2015/306326 | - |
dc.identifier.scopusid | 2-s2.0-84930646910 | - |
dc.identifier.bibliographicCitation | Scientific World Journal, v.2015, pp.1 - 9 | - |
dc.relation.isPartOf | Scientific World Journal | - |
dc.citation.title | Scientific World Journal | - |
dc.citation.volume | 2015 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | activating transcription factor 6 | - |
dc.subject.keywordPlus | alanine aminotransferase | - |
dc.subject.keywordPlus | aspartate aminotransferase | - |
dc.subject.keywordPlus | bilirubin | - |
dc.subject.keywordPlus | fructose | - |
dc.subject.keywordPlus | insulin | - |
dc.subject.keywordPlus | interleukin 6 | - |
dc.subject.keywordPlus | monocyte chemotactic protein 1 | - |
dc.subject.keywordPlus | reduced nicotinamide adenine dinucleotide phosphate oxidase 4 | - |
dc.subject.keywordPlus | toll like receptor 4 | - |
dc.subject.keywordPlus | tumor necrosis factor alpha | - |
dc.subject.keywordPlus | biological marker | - |
dc.subject.keywordPlus | fructose | - |
dc.subject.keywordPlus | alanine aminotransferase blood level | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | aspartate aminotransferase blood level | - |
dc.subject.keywordPlus | carbohydrate diet | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | disease model | - |
dc.subject.keywordPlus | endoplasmic reticulum stress | - |
dc.subject.keywordPlus | inflammation | - |
dc.subject.keywordPlus | lipid diet | - |
dc.subject.keywordPlus | lipid storage | - |
dc.subject.keywordPlus | liver histology | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | metabolism | - |
dc.subject.keywordPlus | nonalcoholic fatty liver | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | oral glucose tolerance test | - |
dc.subject.keywordPlus | oxidative stress | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | rat | - |
dc.subject.keywordPlus | signal transduction | - |
dc.subject.keywordPlus | weight gain | - |
dc.subject.keywordPlus | adverse effects | - |
dc.subject.keywordPlus | animal | - |
dc.subject.keywordPlus | blood analysis | - |
dc.subject.keywordPlus | diet | - |
dc.subject.keywordPlus | disease model | - |
dc.subject.keywordPlus | genetics | - |
dc.subject.keywordPlus | glucose tolerance test | - |
dc.subject.keywordPlus | lipid diet | - |
dc.subject.keywordPlus | liver | - |
dc.subject.keywordPlus | Non-alcoholic Fatty Liver Disease | - |
dc.subject.keywordPlus | pathology | - |
dc.subject.keywordPlus | Animalia | - |
dc.subject.keywordPlus | Rattus | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Biomarkers | - |
dc.subject.keywordPlus | Blood Chemical Analysis | - |
dc.subject.keywordPlus | Diet | - |
dc.subject.keywordPlus | Diet, High-Fat | - |
dc.subject.keywordPlus | Disease Models, Animal | - |
dc.subject.keywordPlus | Endoplasmic Reticulum Stress | - |
dc.subject.keywordPlus | Fructose | - |
dc.subject.keywordPlus | Glucose Tolerance Test | - |
dc.subject.keywordPlus | Liver | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Non-alcoholic Fatty Liver Disease | - |
dc.subject.keywordPlus | Rats | - |
dc.identifier.url | https://www.hindawi.com/journals/tswj/2015/306326/ | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.