Olfactory Performance and Resting State Functional Connectivity in Non-demented Drug Naive Patients with Parkinson's Disease
DC Field | Value | Language |
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dc.contributor.author | Sunwoo, Mun Kyung | - |
dc.contributor.author | Cha, Jungho | - |
dc.contributor.author | Ham, Jee Hyun | - |
dc.contributor.author | Song, Sook K. | - |
dc.contributor.author | Hong, Jin Yong | - |
dc.contributor.author | Lee, Jong-Min | - |
dc.contributor.author | Sohn, Young H. | - |
dc.contributor.author | Lee, Phil Hyu | - |
dc.date.accessioned | 2022-07-15T22:58:46Z | - |
dc.date.available | 2022-07-15T22:58:46Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 1065-9471 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/157313 | - |
dc.description.abstract | Olfactory performance in Parkinson's disease (PD) is closely associated with subsequent cognitive decline. In the present study, we analyzed the olfaction-dependent functional connectivity with a hypothesis that olfactory performance would influence functional connectivity within key brain areas of PD. A total of 110 nondemented drug-naive patients with PD were subdivided into three groups of high score (PD-H, n=23), middle score (PD-M, n=64), and low score (PD-L, n=23) based on olfactory performance. We performed the resting-state functional connectivity with seed region of interest in the posterior cingulate cortex (PCC) and caudate. An analysis of functional connectivity revealed that PD-L patients exhibited a significant attenuation of cortical functional connectivity with the PCC in the bilateral primary sensory areas, right frontal areas, and right parietal areas compared to PD-H or PD-M patients. Meanwhile, PD-L patients exhibited a significant enhancement of striatocortical functional connectivity in the bilateral occipital areas and right frontal areas compared to PD-H or PD-M patients. In the voxel-wise correlation analysis, olfactory performance was positively associated with cortical functional connectivity with the PCC in similar areas of attenuated cortical connectivity in PD-L patients relative to PD-H patients. On the other hand, the cortical functional connectivity with the caudate was negatively correlated with olfactory performance in similar areas of increased connectivity in PD-L patients relative to PD-H patients. The present study demonstrated that resting state functional connectivity exhibits a distinctive pattern depending on olfactory performance, which might shed light on a meaningful relationship between olfactory impairment and cognitive dysfunction in PD. Hum Brain Mapp 36:1716-1727, 2015. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Olfactory Performance and Resting State Functional Connectivity in Non-demented Drug Naive Patients with Parkinson's Disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jong-Min | - |
dc.identifier.doi | 10.1002/hbm.22732 | - |
dc.identifier.scopusid | 2-s2.0-84927609746 | - |
dc.identifier.wosid | 000353068300007 | - |
dc.identifier.bibliographicCitation | HUMAN BRAIN MAPPING, v.36, no.5, pp.1716 - 1727 | - |
dc.relation.isPartOf | HUMAN BRAIN MAPPING | - |
dc.citation.title | HUMAN BRAIN MAPPING | - |
dc.citation.volume | 36 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1716 | - |
dc.citation.endPage | 1727 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Neuroimaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | ODOR IDENTIFICATION DEFICITS | - |
dc.subject.keywordPlus | AUTOMATED 3-D EXTRACTION | - |
dc.subject.keywordPlus | DEFAULT-MODE NETWORK | - |
dc.subject.keywordPlus | COGNITIVE IMPAIRMENT | - |
dc.subject.keywordPlus | CEREBRAL-CORTEX | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | REGISTRATION | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | FMRI | - |
dc.subject.keywordAuthor | Parkinson&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | resting state functional connectivity | - |
dc.subject.keywordAuthor | olfaction | - |
dc.subject.keywordAuthor | cognition | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/hbm.22732 | - |
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