Preconditioning Strategies for Kidney Ischemia Reperfusion Injury: Implications of the “Time-Window” in Remote Ischemic Preconditioning
DC Field | Value | Language |
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dc.contributor.author | Yoon, YOUNG EUN | - |
dc.contributor.author | Lee, Kwang Suk | - |
dc.contributor.author | Choi, Kyung Hwa | - |
dc.contributor.author | Kim, Kwang Hyun | - |
dc.contributor.author | Yang, Seung Choul | - |
dc.contributor.author | Han, Woong Kyu | - |
dc.date.accessioned | 2022-07-15T23:19:09Z | - |
dc.date.available | 2022-07-15T23:19:09Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2015-04 | - |
dc.identifier.issn | 19326203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/157468 | - |
dc.description.abstract | Remote ischemic preconditioning (IP) is a potential renoprotective strategy. However, there has been no demonstrated result in large animals and the role of time window in remote IP remains to be defined. Using a single-kidney porcine model, we evaluated organ protective function of remote IP in renal ischemia reperfusion injury. Fifteen Yorkshire pigs, 20 weeks old and weighing 35-38 kg were used. One week after left nephrectomy, we performed remote IP (clamping right external iliac artery, 2 cycles of 10 minutes) and right renal artery clamping (warm ischemia; 90 minutes). The animals were randomly divided into three groups: control group, warm ischemia without IP; group 1 (remote IP with early window [IP-E]), IP followed by warm ischemia with a 10-minute time window; and group 2 (remote IP with late window [IP-L]), IP followed by warm ischemia after a 24-hour time window. There were no differences in serum creatinine changes between groups. The IP-L group had lower urinary neutrophil gelatinase-associated lipocalin than control and IP-E at 72 hours post-ischemia. At 72 hours post-ischemia, the urinary kidney injury molecule-1 (KIM-1) was lower in the IP-L group than in the control and IP-E groups, and the IP-L group KIM-1 was near pre-ischemic levels, whereas the control and IP-E group KIM-1 levels were rising. Microalbumin also tended to be lower in the IP-L group. Taken together, remote IP showed a significant reduction in renal injury biomarkers from ischemia reperfusion injury. To effectively provide kidney protection, remote IP might require a considerable, rather than short, time window of ischemia. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Preconditioning Strategies for Kidney Ischemia Reperfusion Injury: Implications of the “Time-Window” in Remote Ischemic Preconditioning | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, YOUNG EUN | - |
dc.identifier.doi | 10.1371/journal.pone.0124130 | - |
dc.identifier.scopusid | 2-s2.0-84928492377 | - |
dc.identifier.wosid | 000353016500084 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.10, no.4, pp.1 - 11 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordAuthor | GENE-EXPRESSION | - |
dc.subject.keywordAuthor | RENAL ISCHEMIA | - |
dc.subject.keywordAuthor | NITRIC-OXIDE | - |
dc.subject.keywordAuthor | PROTECTION | - |
dc.subject.keywordAuthor | RAT | - |
dc.subject.keywordAuthor | CELLS | - |
dc.subject.keywordAuthor | MECHANISMS | - |
dc.subject.keywordAuthor | BIOMARKERS | - |
dc.subject.keywordAuthor | ADENOSINE | - |
dc.subject.keywordAuthor | HEART | - |
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