Sevoflurane post-conditioning increases nuclear factor erythroid 2-related factor and haemoxygenase-1 expression via protein kinase C pathway in a rat model of transient global cerebral ischaemia.
DC Field | Value | Language |
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dc.contributor.author | Kim, Eu gene | - |
dc.contributor.author | Park, Y. H. | - |
dc.contributor.author | Jeon, Y. T. | - |
dc.contributor.author | Hwang, J. W. | - |
dc.contributor.author | Lim, Y. J. | - |
dc.contributor.author | Kim, E. | - |
dc.contributor.author | Park, S. Y. | - |
dc.contributor.author | Park, H. P. | - |
dc.date.accessioned | 2022-07-16T00:17:05Z | - |
dc.date.available | 2022-07-16T00:17:05Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 0007-0912 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/157888 | - |
dc.description.abstract | Background. The antioxidant mechanism of sevoflurane post-conditioning-induced neuroprotection remains unclear. We determined whether sevoflurane post-conditioning induces nuclear factor erythroid 2-related factor (Nrf2, a master transcription factor regulating antioxidant defence genes) and haemoxygenase-1 (HO-1, an antioxidant enzyme) expression, and whether protein kinase C (PKC) is involved in Nrf2 activation, in a rat model of transient global cerebral ischaemia/reperfusion (I/R) injury. Methods. Eighty-six rats were assigned to five groups: sham (n=6), control (n=20), sevoflurane post-conditioning (two cycles with 2 vol% sevoflurane inhalation for 10 min, n=20), chelerythrine (a PKC inhibitor; 5 mg kg(-1) i.v. administration, n=20), and sevoflurane post-conditioning plus chelerythrine (n=20). The levels of nuclear Nrf2 and cytoplasmic HO-1 were assessed 1 or 7 days after ischaemia (n=10 each, apart from the sham group, n=3). Results. On day 1 but not day 7 post-ischaemia, Nrf2 and HO-1 expression were significantly higher in the sevoflurane post-conditioning group than in the control group. Chelerythrine administration reduced the elevated Nrf2 and HO-1 expression induced by sevoflurane post-conditioning. Conclusions. Sevoflurane post-conditioning increased Nrf2/HO-1 expression via PKC signalling in the early phase after transient global cerebral I/R injury, suggesting that activation of antioxidant enzymes may be responsible for sevoflurane post-conditioning-induced neuroprotection in the early phase after cerebral I/R injury. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | Sevoflurane post-conditioning increases nuclear factor erythroid 2-related factor and haemoxygenase-1 expression via protein kinase C pathway in a rat model of transient global cerebral ischaemia. | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Eu gene | - |
dc.identifier.doi | 10.1093/bja/aeu268 | - |
dc.identifier.scopusid | 2-s2.0-84922565684 | - |
dc.identifier.wosid | 000348889200018 | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF ANAESTHESIA, v.114, no.2, pp.307 - 318 | - |
dc.relation.isPartOf | BRITISH JOURNAL OF ANAESTHESIA | - |
dc.citation.title | BRITISH JOURNAL OF ANAESTHESIA | - |
dc.citation.volume | 114 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 307 | - |
dc.citation.endPage | 318 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Anesthesiology | - |
dc.relation.journalWebOfScienceCategory | Anesthesiology | - |
dc.subject.keywordPlus | PRECONDITIONING ATTENUATES APOPTOSIS | - |
dc.subject.keywordPlus | ANTIOXIDANT RESPONSE ELEMENT | - |
dc.subject.keywordPlus | REPERFUSION INJURY | - |
dc.subject.keywordPlus | DELAYED NEUROPROTECTION | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | ACTIVATES NRF2 | - |
dc.subject.keywordPlus | CELL-SURVIVAL | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | EPSILON | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordAuthor | anaesthetics, inhalation | - |
dc.subject.keywordAuthor | GA-binding protein transcription factor | - |
dc.subject.keywordAuthor | haeme oxygenase-1 | - |
dc.subject.keywordAuthor | protein kinase C | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0007091217317233?pes=vor | - |
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