Gintonin, a novel ginseng-derived lysophosphatidic acid receptor ligand, stimulates neurotransmitter release
DC Field | Value | Language |
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dc.contributor.author | Hwang, Sung-Hee | - |
dc.contributor.author | Lee, Byung-Hwan | - |
dc.contributor.author | Choi, Sun-Hye | - |
dc.contributor.author | Kim, Hyeon-Joong | - |
dc.contributor.author | Jung, Seok-Won | - |
dc.contributor.author | Kim, Hyun-Sook | - |
dc.contributor.author | Shin, Ho-Chul | - |
dc.contributor.author | Park, Hyun Jin | - |
dc.contributor.author | Park, Keun Hong | - |
dc.contributor.author | Lee, Myung Koo | - |
dc.contributor.author | Nah, Seung-Yeol | - |
dc.date.accessioned | 2022-07-16T00:48:27Z | - |
dc.date.available | 2022-07-16T00:48:27Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158027 | - |
dc.description.abstract | Gintonin is a novel ginseng-derived G protein-coupled lysophosphatidic acid (LPA) receptor ligand. Gintonin elicits an intracellular calcium concentration [Ca2+](i) transient via activation of LPA receptors and regulates calcium-dependent ion channels and receptors. [Ca2+](i) elevation by neurotransmitters or depolarization is usually coupled to neurotransmitter release in neuronal cells. Little is known about whether gintonin-mediated [Ca2+](i) transients.are also coupled to neurotransmitter release. The PC12 cell line is derived from a pheochromocytoma of the rat adrenal medulla and is widely used as a model for catecholamine release. In the present study, we examined the effects of gintonin on dopamine release in PC12 cells. Application of gintonin to PC12 cells induced [Ca2+](i) transients in concentration-dependent and reversible manners. However, ginsenoside Rg(3), another active ingredient of ginseng, induced a lagged and irreversible [Ca2+](i) increase. The induction of gintonin-mediated [Ca2+](i) transients was attenuated or blocked by the LPA1/3 receptor antagonist Ki16425, a phospholipase C inhibitor, an inositol 1,4,5-triphosphate receptor antagonist, and an intracellular Ca2+ chelator. Repeated treatment with gintonin induced homologous desensitization of [Ca2+](i) transients. Gintonin treatment in PC12 cells increased the release of dopamine in a concentration-dependent manner. Intraperitoneal administration of gintonin to mice also increased serum dopamine concentrations. The present study shows that gintonin-mediated [Ca2+](i) transients are coupled to dopamine release via LPA receptor activation. Finally, gintonin-mediated [Ca2+](i) transients and dopamine release via LPA receptor activation might explain one mechanism of gintonin-mediated inter-neuronal modulation in the nervous system. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | Gintonin, a novel ginseng-derived lysophosphatidic acid receptor ligand, stimulates neurotransmitter release | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyun-Sook | - |
dc.identifier.doi | 10.1016/j.neulet.2014.11.007 | - |
dc.identifier.scopusid | 2-s2.0-84918824443 | - |
dc.identifier.wosid | 000347579000067 | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE LETTERS, v.584, pp.356 - 361 | - |
dc.relation.isPartOf | NEUROSCIENCE LETTERS | - |
dc.citation.title | NEUROSCIENCE LETTERS | - |
dc.citation.volume | 584 | - |
dc.citation.startPage | 356 | - |
dc.citation.endPage | 361 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | ADRENAL CHROMAFFIN CELLSCATECHOLAMINE SECRETIONPHEOCHROMOCYTOMA CELLSNERVOUS-SYSTEMLPA RECEPTORSPC12 CELLSINVOLVEMENTACTIVATIONLINE | - |
dc.subject.keywordAuthor | GinsengGintoninLPA receptor[Ca2+](i) transientDopamineNeurotransmitter release | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S030439401400874X?via%3Dihub | - |
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