Ileal mass-like lesion induced by Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in a patient with aplastic anemia
DC Field | Value | Language |
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dc.contributor.author | Min, Kyueng Whan | - |
dc.contributor.author | Jung, Ho Young | - |
dc.contributor.author | Han, Hye Seung | - |
dc.contributor.author | Hwang, Tae Sook | - |
dc.contributor.author | Kim, Sung-Yong | - |
dc.contributor.author | Kim, Wan Seop | - |
dc.contributor.author | Lim, So Dug | - |
dc.contributor.author | Kim, Wook Youn | - |
dc.date.accessioned | 2022-07-16T00:48:57Z | - |
dc.date.available | 2022-07-16T00:48:57Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.issn | 09034641 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158032 | - |
dc.description.abstract | Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening hyperinflammatory syndrome characterized by activated macrophages engulfing erythrocytes, leukocytes, platelets, and their precursor cells in bone marrow, liver, spleen, or lymph nodes. We report a case of Epstein-Barr virus (EBV)-associated HLH unusually presenting as an ileal mass. A 23-year-old man presented initially with persistent fever unresponsive to antibiotics and pancytopenia. A bone marrow aspiration and biopsy were used to diagnose the patient with aplastic anemia and HLH. A relatively well-defined low-density mass was radiologically noted in the terminal ileum, along with enlarged lymph nodes, and was suspected to be malignant lymphoma or an abscess. The ileocecectomy specimen revealed a transmural hemorrhagic infarction with numerous activated macrophages phagocytosing erythrocytes, plasma cells, and lymphocytes, and he was diagnosed with EBV-associated HLH. The patient received an allo-unrelated peripheral blood stem-cell transplantation and expired due to graft-versus-host disease following liver failure. The present case is very unique, in that EBV-associated HLH presented with an unusual ileal mass resulting from hemorrhagic infarction in a patient with aplastic anemia, suggesting variability in the biological behavior of EBV-associated disease. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Ileal mass-like lesion induced by Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in a patient with aplastic anemia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Min, Kyueng Whan | - |
dc.identifier.doi | 0.1111/apm.12308 | - |
dc.identifier.scopusid | 2-s2.0-84921033507 | - |
dc.identifier.wosid | 000347055100012 | - |
dc.identifier.bibliographicCitation | APMIS, v.123, no.1, pp.81 - 86 | - |
dc.relation.isPartOf | APMIS | - |
dc.citation.title | APMIS | - |
dc.citation.volume | 123 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 81 | - |
dc.citation.endPage | 86 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | NONIMMUNOCOMPROMISED HOSTS | - |
dc.subject.keywordPlus | PATHOPHYSIOLOGY | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | EBV | - |
dc.subject.keywordAuthor | Lymphohistiocytosis | - |
dc.subject.keywordAuthor | hemophagocytic | - |
dc.subject.keywordAuthor | aplastic anemia | - |
dc.subject.keywordAuthor | EBV | - |
dc.subject.keywordAuthor | ileum | - |
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