1 alpha,25-Dihydroxyvitamin D-3 upregulates HIF-1 and TREM-1 via mTOR signaling
DC Field | Value | Language |
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dc.contributor.author | Lee, Bitnara | - |
dc.contributor.author | Kwon, Eunji | - |
dc.contributor.author | Kim, Yongjin | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Son, Sang Wook | - |
dc.contributor.author | Lee, Jin Kyu | - |
dc.contributor.author | Kim, Dong Won | - |
dc.contributor.author | Sohn, Jeongwon | - |
dc.contributor.author | Kim, Tae-Hwan | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.date.accessioned | 2022-07-16T00:56:40Z | - |
dc.date.available | 2022-07-16T00:56:40Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.issn | 0165-2478 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158116 | - |
dc.description.abstract | Triggering receptor expressed on myeloid cells-1 (TREM-1) is induced by 1 alpha,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3) in human monocytes/macrophages and epithelial cells. However, little information is available regarding the mechanism of 1,25(OH)(2)D-3-induced TREM-1 expression in human monocytes/macrophages. In this study, 1,25(OH)(2)D-3 was shown to strongly upregulate hypoxia-inducible transcription factor (HIF) in PMA-differentiated U937 cells. However, HIF was not mainly involved in 1,25(OH)(2)D-3-induced TREM-1 expression. Instead, 1,25(OH)(2)D-3-induced expression of TREM-1 was inhibited by rapamycin, a specific inhibitor of the mammalian target of rapamycin (mTOR) signaling pathway, indicating the involvement of mTOR. Induction of HIF proteins by 1,25(OH)(2)D-3 was also inhibited by rapamycin. In addition, 1,25(OH)(2)D-3 induced the phosphorylation of p70S6 kinase, a target of mTOR complex 1 (mTORC1). Our results suggest that 1,25(OH)(2)D-3 induces the expression of TREM-1 through the mTOR signaling pathway in human macrophages. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | 1 alpha,25-Dihydroxyvitamin D-3 upregulates HIF-1 and TREM-1 via mTOR signaling | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jin Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Dong Won | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Hwan | - |
dc.identifier.doi | 10.1016/j.imlet.2014.11.004 | - |
dc.identifier.scopusid | 2-s2.0-84912124847 | - |
dc.identifier.wosid | 000348628900003 | - |
dc.identifier.bibliographicCitation | IMMUNOLOGY LETTERS, v.163, no.1, pp.14 - 21 | - |
dc.relation.isPartOf | IMMUNOLOGY LETTERS | - |
dc.citation.title | IMMUNOLOGY LETTERS | - |
dc.citation.volume | 163 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 14 | - |
dc.citation.endPage | 21 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | HYPOXIA-INDUCIBLE FACTORS | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | MAMMALIAN TARGET | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | HYPOXIA-INDUCIBLE-FACTOR-1-ALPHA | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordAuthor | TREM-1 | - |
dc.subject.keywordAuthor | 1 alpha,25-dihydroxyviamin D-3 | - |
dc.subject.keywordAuthor | mTOR | - |
dc.subject.keywordAuthor | Monocytes | - |
dc.subject.keywordAuthor | Macrophages | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0165247814002582?via%3Dihub | - |
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