Foxp3(+) regulatory T cells ensure B lymphopoiesis by inhibiting the granulopoietic activity of effector T cells in mouse bone marrow
DC Field | Value | Language |
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dc.contributor.author | Kim, Sunghoon | - |
dc.contributor.author | Park, Kyungsoo | - |
dc.contributor.author | Choi, Jinwook | - |
dc.contributor.author | Jang, Eunkyeong | - |
dc.contributor.author | Paik, Doo-Jin | - |
dc.contributor.author | Seong, Rho H. | - |
dc.contributor.author | Youn, Jeehee | - |
dc.date.accessioned | 2022-07-16T00:57:02Z | - |
dc.date.available | 2022-07-16T00:57:02Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.issn | 0014-2980 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158119 | - |
dc.description.abstract | Foxp3⁺ Treg cells are crucial for maintaining T-cell homeostasis, but their role in B-cell homeostasis remains unclear. Here, we found that Foxp3 mutant scurfy mice had fewer B-lineage cells and progenitors, including common lymphoid progenitors and lymphoid-primed multipotent progenitors, but higher myeloid-lineage cell numbers in BM compared with WT littermates. Homeostasis within the HSC compartment was also compromised with apparent expansion of long- and short-term HSCs. This abnormality was due to the lack of Treg cells, but not to the Treg-cell extrinsic functions of Foxp3 or cell-autonomous defects. Among cytokines enriched in the BM of scurfy mice, IFN- affected only B lymphopoiesis, but GM-CSF, TNF, and IL-6 collectively promoted granulopoiesis at the expense of B lymphopoiesis. Neutralization of these three cytokines reversed the hematopoietic defects on early B-cell progenitors in scurfy mice. Treg cells ensured B lymphopoiesis by reducing the production of these cytokines by effector T cells, but not by directly affecting B lymphopoiesis. These results suggest that Treg cells occupy an important niche in the BM to protect B-lineage progenitor cells from excessive exposure to a lymphopoiesis-regulating milieu. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Foxp3(+) regulatory T cells ensure B lymphopoiesis by inhibiting the granulopoietic activity of effector T cells in mouse bone marrow | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Paik, Doo-Jin | - |
dc.contributor.affiliatedAuthor | Youn, Jeehee | - |
dc.identifier.doi | 10.1002/eji.201444532 | - |
dc.identifier.scopusid | 2-s2.0-84921061600 | - |
dc.identifier.wosid | 000347955100018 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF IMMUNOLOGY, v.45, no.1, pp.167 - 179 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF IMMUNOLOGY | - |
dc.citation.title | EUROPEAN JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 45 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 167 | - |
dc.citation.endPage | 179 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | HEMATOPOIETIC STEM-CELLS | - |
dc.subject.keywordPlus | EMERGENCY GRANULOPOIESIS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | PROGENITORS | - |
dc.subject.keywordPlus | TRAFFICKING | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | B lymphopoiesis | - |
dc.subject.keywordAuthor | Foxp3 | - |
dc.subject.keywordAuthor | Granulopoietins | - |
dc.subject.keywordAuthor | Hematopoiesis | - |
dc.subject.keywordAuthor | Regulatory T cells | - |
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