The Effect of a Single Dose of Preemptive Pregabalin Administered With COX-2 Inhibitor: A Trial in Total Knee Arthroplasty
- Authors
- Lee, Jin Kyu; Chung, Kyu-Sung; Choi, Choong Hyeok
- Issue Date
- Jan-2015
- Publisher
- CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
- Keywords
- knee; total knee arthroplasty; preemptive analgesia; acute postoperative pain; pregabalin
- Citation
- JOURNAL OF ARTHROPLASTY, v.30, no.1, pp.38 - 42
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF ARTHROPLASTY
- Volume
- 30
- Number
- 1
- Start Page
- 38
- End Page
- 42
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158130
- DOI
- 10.1016/j.arth.2014.04.004
- ISSN
- 0883-5403
- Abstract
- We sought to compare a group (Group L) (n = 21) of patients that underwent total knee arthroplasty and received a single preoperative dose of pregabalin combined with a COX-2 inhibitor with a control group (Group C) (n = 20) that only received a COX-2 inhibitor in terms of (1) acute postoperative pain intensity, (2) analgesic consumption, and (3) functional recovery. Mean cumulative fentanyl consumption during the first 48 hours was lower in Group L than in Group C (P < 0.05). The pain scores at rest were lower in Group L at 6 and 12 hours after surgery (P < 0.05). No significant intergroup difference was noted in functional recovery. The addition of pregabalin led to an additive reduction in early postoperative pain and analgesic consumption.
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