Superoxide Dismutase Gene (SOD 1, SOD2, and SOD3) Polymorphisms and Antituberculosis Drug-induced Hepatitis
DC Field | Value | Language |
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dc.contributor.author | Kim, Sang-Hoon | - |
dc.contributor.author | Kim, Sang-Heon | - |
dc.contributor.author | Lee, Jae-Hyoung | - |
dc.contributor.author | Lee, Byoung-Hoon | - |
dc.contributor.author | Yoon, Ho Joo | - |
dc.contributor.author | Shin, Dong Ho | - |
dc.contributor.author | Park, Sung Soo | - |
dc.contributor.author | Bin Jang, Suk | - |
dc.contributor.author | Park, Jae-Seuk | - |
dc.contributor.author | Jee, Young-Koo | - |
dc.date.accessioned | 2022-07-16T01:02:09Z | - |
dc.date.available | 2022-07-16T01:02:09Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158162 | - |
dc.description.abstract | Purpose: Drug-induced liver injury (DILI) is a serious issue often leading to discontinuation of the proper regimen of antituberculosis drugs (AID). Previous studies have suggested that antioxidant enzymes play an important role in DILI. Methods: We explored whether polymorphisms in superoxide dismutase genes, including Cu/Zn superoxide dismutase (SOD1), manganese superoxide dismutase (SOD2) and extracellular superoxide dismutase (SOD3) are associated with AID-induced hepatitis. Genotype distributions of four single nucleotide polymorphisms (SNPs) in three genes (rs2070424, SOD1; rs4880, SOD2; rs2536512, and rs1799895, SOD3) were compared between 84 patients with ATD-induced hepatitis and 237 patients tolerant to ATD. Results: Intron SNP rs2070424 of SOD1 showed a significant association with AID-induced hepatitis. The frequency of genotypes carrying minor Results (GA or GO) was significantly higher in the case group than that of controls (P=0.019, OR= 2.26, 95% CI 1.14-4.49). For the other SNPs of SOD2 and SOD3, there were no differences in genotype frequencies between AID-induced hepatitis and ATD-tolerant controls. Conclusions: These findings suggest that rs2070424 of SOD1 is significantly associated with AID-induced hepatitis. This genetic variant may be a risk factor for AID-induced hepatitis in individuals from Korea. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY | - |
dc.title | Superoxide Dismutase Gene (SOD 1, SOD2, and SOD3) Polymorphisms and Antituberculosis Drug-induced Hepatitis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sang-Heon | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Joo | - |
dc.identifier.doi | 10.4168/aair.2015.7.1.88 | - |
dc.identifier.scopusid | 2-s2.0-84919354986 | - |
dc.identifier.wosid | 000350833000013 | - |
dc.identifier.bibliographicCitation | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, v.7, no.1, pp.88 - 91 | - |
dc.relation.isPartOf | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.citation.title | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.citation.volume | 7 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 88 | - |
dc.citation.endPage | 91 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001942788 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | INDUCED LIVER-INJURY | - |
dc.subject.keywordPlus | METABOLIZING-ENZYMES | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordAuthor | Antituberculosis drugs | - |
dc.subject.keywordAuthor | hepatitis | - |
dc.subject.keywordAuthor | superoxide dismutase | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.identifier.url | https://e-aair.org/DOIx.php?id=10.4168/aair.2015.7.1.88 | - |
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