Profiling of Proteins Regulated by Venlafaxine during Neural Differentiation of Human Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Doh, Mi Sook | - |
dc.contributor.author | Han, Dal Mu Ri | - |
dc.contributor.author | Oh, Dong Hoon | - |
dc.contributor.author | Kim, Seok Hyeon | - |
dc.contributor.author | Choi, Mi Ran | - |
dc.contributor.author | Chai, Young Gyu | - |
dc.date.accessioned | 2022-07-16T01:07:39Z | - |
dc.date.available | 2022-07-16T01:07:39Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.issn | 1738-3684 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158219 | - |
dc.description.abstract | Objective Antidepressants are known to positively influence several factors in patients with depressive disorders, resulting in increased neurogenesis and subsequent relief of depressive disorders. To study the effects of venlafaxine during neural differentiation at the cellular level, we looked at its effect on protein expression and regulation mechanisms during neural differentiation. Methods After exposing NCCIT cell-derived EBs to venlafaxine during differentiation (1 day and 7 days), changes in protein expression were analyzed by 2-DE and MALDI-TOF MS analysis. Gene levels of proteins regulated by venlafaxine were analyzed by real-time RT-PCR. Results Treatment with venlafaxine decreased expression of prolyl 4-hydroxylase (P4HB), ubiquitin-conjugating enzyme E2K (HIP2) and plastin 3 (T-plastin), and up-regulated expression of growth factor beta-3 (TGF-beta 3), dihydropyrimidinase-like 3 (DPYSL3), and pyruvate lcinase (PKM) after differentiation for 1 and 7 days. In cells exposed to venlafaxine, the mRNA expression patterns of HIP2 and PKM, which function as negative and positive regulators of differentiation and neuronal survival, respectively, were consistent with the observed changes in protein expression. Conclusion Our findings may contribute to improve understanding of molecular mechanism of venlafaxine. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN NEUROPSYCHIATRIC ASSOC | - |
dc.title | Profiling of Proteins Regulated by Venlafaxine during Neural Differentiation of Human Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Seok Hyeon | - |
dc.identifier.doi | 10.4306/pi.2015.12.1.81 | - |
dc.identifier.scopusid | 2-s2.0-84921979648 | - |
dc.identifier.wosid | 000348258800012 | - |
dc.identifier.bibliographicCitation | PSYCHIATRY INVESTIGATION, v.12, no.1, pp.81 - 91 | - |
dc.relation.isPartOf | PSYCHIATRY INVESTIGATION | - |
dc.citation.title | PSYCHIATRY INVESTIGATION | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 81 | - |
dc.citation.endPage | 91 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002015690 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | CHRONIC ANTIDEPRESSANT TREATMENT | - |
dc.subject.keywordPlus | PROTEOMIC ANALYSIS | - |
dc.subject.keywordPlus | NEURONAL DIFFERENTIATION | - |
dc.subject.keywordPlus | HIPPOCAMPAL NEUROGENESIS | - |
dc.subject.keywordPlus | DISULFIDE-ISOMERASE | - |
dc.subject.keywordPlus | PYRUVATE-KINASE | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INCREASES | - |
dc.subject.keywordAuthor | Venlafaxine | - |
dc.subject.keywordAuthor | Depression | - |
dc.subject.keywordAuthor | NCCIT cells | - |
dc.subject.keywordAuthor | Proteomics | - |
dc.subject.keywordAuthor | HIP2 | - |
dc.subject.keywordAuthor | Pyruvate kinase | - |
dc.identifier.url | https://www.psychiatryinvestigation.org/journal/view.php?doi=10.4306/pi.2015.12.1.81 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.