The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin.
DC Field | Value | Language |
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dc.contributor.author | Kim, Won-Serk | - |
dc.contributor.author | Seo, Hyun Min | - |
dc.contributor.author | Kim, Wang-Kyun | - |
dc.contributor.author | Choi, Joon-Seok | - |
dc.contributor.author | Kim, Ikyon | - |
dc.contributor.author | Sung, Jong-Hyuk | - |
dc.date.accessioned | 2022-07-16T01:09:02Z | - |
dc.date.available | 2022-07-16T01:09:02Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158235 | - |
dc.description.abstract | S-Methylmethionine sulfonium (SMMS) was reported to have wound-healing effects; we therefore have investigated the photoprotective effect of SMMS in the present study. SMMS increased the viability of keratinocyte progenitor cells (KPCs) and human dermal fibroblasts (hDFs) following ultraviolet B (UVB) irradiation, and reduced the UVB-induced apoptosis in these cells. SMMS increased the phosphorylation of extracellular signal-regulated kinases (ERK), and the inhibitor of the mitogen-activated protein kinase pathway significantly decreased the SMMS-induced viability of KPCs and hDFs. In addition, SMMS attenuated the UVB-induced reactive oxygen species (ROS) generation in KPCs and hDFs. SMMS induced the collagen synthesis and reduced the matrix metalloproteinase-1 expression in UVB-irradiated hDFs. In animal studies, application of 5% and 10% SMMS before and after UVB-irradiation significantly decreased the UVB-induced erythema index and depletion of Langerhans cells. In summary, SMMS protects KPCs and hDFs from UVB irradiation, and reduces UVB-induced skin erythema and immune suppression. Therefore, SMMS can be used as a cosmetic raw material, and protect skin from UVB. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.title | The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin. | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seo, Hyun Min | - |
dc.identifier.doi | 10.3390/ijms160817088 | - |
dc.identifier.scopusid | 2-s2.0-84938153204 | - |
dc.identifier.wosid | 000366826100022 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.16, no.8, pp.17088 - 17100 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 16 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 17088 | - |
dc.citation.endPage | 17100 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | DERMAL FIBROBLAST | - |
dc.subject.keywordPlus | INDUCED ERYTHEMA | - |
dc.subject.keywordPlus | UVB | - |
dc.subject.keywordPlus | P53 | - |
dc.subject.keywordPlus | RADIATION | - |
dc.subject.keywordPlus | CHLORIDE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | SENESCENCE | - |
dc.subject.keywordAuthor | Dermal fibroblasts | - |
dc.subject.keywordAuthor | Erythema | - |
dc.subject.keywordAuthor | Keratinocyte progenitor cells | - |
dc.subject.keywordAuthor | S-methylmethionine sulfonium | - |
dc.subject.keywordAuthor | UVB protection | - |
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