Transplanted Human Amniotic Epithelial Cells Secrete Paracrine Proangiogenic Cytokines in Rat Model of Myocardial Infarction
DC Field | Value | Language |
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dc.contributor.author | Song, Yi-Sun | - |
dc.contributor.author | Joo, Hyun-Woo | - |
dc.contributor.author | Park, In-Hwa | - |
dc.contributor.author | Shen, Guang-Yin | - |
dc.contributor.author | Lee, Yonggu | - |
dc.contributor.author | Shin, Jeong Hun | - |
dc.contributor.author | Kim, Hyuck | - |
dc.contributor.author | Shin, Il-Seob | - |
dc.contributor.author | Kim, Kyung-Soo | - |
dc.date.accessioned | 2022-07-16T01:14:10Z | - |
dc.date.available | 2022-07-16T01:14:10Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0963-6897 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158302 | - |
dc.description.abstract | Human amniotic epithelial cells (h-ABCs) have been shown to differentiate into cardiomyocyte-like cells in vivo that can regenerate myocardial tissue and improve cardiac function in a rat model of myocardial infarction (MI). In this study, we investigated the paracrine factors released from h-AECs under hypoxic conditions to elucidate the possible mechanisms underlying this previously reported phenomenon of h-AEC-mediated cardiac repair. We used hypoxic cell culture conditions to simulate myocardial infarction in vitro. In comparison to normal conditions, we found that h-ABCs secreted higher levels of several cytokines, including angiogenin (ANG), epidermal growth factor (EGF), interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1. To determine whether transplanted h-ABCs express these proangiogenic cytokines in vivo, we ligated the coronary artery of rats to cause MI and injected either h-ABCs or saline into the infarcted area. We found that the infarct and border zones of rat myocardium treated with h-AECs had higher expression levels of the human-origin cytokines ANG, EGF, IL-6, and MCP-1 compared to the tissues of saline-treated rats. In conclusion, h-ABCs secreted proangiogenic cytokines in a rat model of MI, which may suggest that the paracrine effect by h-ABCs could regenerate myocardial tissue and improve cardiac function. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS INC | - |
dc.title | Transplanted Human Amniotic Epithelial Cells Secrete Paracrine Proangiogenic Cytokines in Rat Model of Myocardial Infarction | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Yonggu | - |
dc.contributor.affiliatedAuthor | Shin, Jeong Hun | - |
dc.contributor.affiliatedAuthor | Kim, Hyuck | - |
dc.identifier.doi | 10.3727/096368914X685609 | - |
dc.identifier.scopusid | 2-s2.0-84943225562 | - |
dc.identifier.wosid | 000362861200011 | - |
dc.identifier.bibliographicCitation | CELL TRANSPLANTATION, v.24, no.10, pp.2055 - 2064 | - |
dc.relation.isPartOf | CELL TRANSPLANTATION | - |
dc.citation.title | CELL TRANSPLANTATION | - |
dc.citation.volume | 24 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2055 | - |
dc.citation.endPage | 2064 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | CARDIAC-FUNCTION | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | HEART | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordAuthor | Amniotic epithelial cells | - |
dc.subject.keywordAuthor | Myocardial infarction (MI) | - |
dc.subject.keywordAuthor | Paracrine | - |
dc.subject.keywordAuthor | Cytokine | - |
dc.identifier.url | https://journals.sagepub.com/doi/10.3727/096368914X685609 | - |
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