Clinical characteristics of symptomatic clostridium difficile infection in children: Conditions as infection risks and whether probiotics is effective
DC Field | Value | Language |
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dc.contributor.author | Na, Jae Yoon | - |
dc.contributor.author | Park, Jong Mo | - |
dc.contributor.author | Lee, Kyung Suk | - |
dc.contributor.author | Kang, Jung Oak | - |
dc.contributor.author | Oh, Sung Hee | - |
dc.contributor.author | Kim, Yong Joo | - |
dc.date.accessioned | 2022-07-16T01:30:56Z | - |
dc.date.available | 2022-07-16T01:30:56Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2014-12 | - |
dc.identifier.issn | 2234-8646 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158414 | - |
dc.description.abstract | Purpose: This study investigated the clinical presentations of symptomatic Clostridium difficile infection (CDI) in children. Methods: We reviewed the medical records of 43 children aged < 20 years who showed either positive C. difficile culture or C. difficile toxin test results between June 2010 and April 2014. Results: Of the 43 patients (mean age 6.7 years), 22 were boys. Sixteen patients (37.2%) showed both positive C. difficile culture and toxin test results. Seventeen out of 43 children (39.5%) had preexisting gastrointestinal diseases, and 26 children had other medical conditions that were risk factors for CDI. Twenty-eight children had a history of antibiotic treatment for > 3 days, and the most frequently prescribed antibiotic was amoxicillin-clavulanate (35.7%). Twenty-eight patients were diagnosed with CDI despite taking probiotic supplements, most commonly Lactobacillus acidophilus (53.6%). The most common symptom was diarrhea (72.1%) at the time CDI was diagnosed. C. difficile was eradicated in 11 patients (25.6%) after treatment with oral metronidazole for 10-14 days, and in the two patients (4.6%) who required two courses of oral metronidazole. Sixteen patients (37.2%) showed clinical improvement without any treatment. Conclusion: This study showed the various clinical characteristics of CDI in children and that preexisting clinical conditions favored the development of CDI. In addition, CDI was found to occur in a number of patients even after probiotic prophylaxis given in conjunction with antibiotic therapy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Korean Society of Pediartic Gastroenterology, Hepatology and Nutrition | - |
dc.title | Clinical characteristics of symptomatic clostridium difficile infection in children: Conditions as infection risks and whether probiotics is effective | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Suk | - |
dc.contributor.affiliatedAuthor | Kim, Yong Joo | - |
dc.identifier.doi | 10.5223/pghn.2014.17.4.232 | - |
dc.identifier.scopusid | 2-s2.0-84944189457 | - |
dc.identifier.bibliographicCitation | Pediatric Gastroenterology, Hepatology and Nutrition, v.17, no.4, pp.232 - 238 | - |
dc.relation.isPartOf | Pediatric Gastroenterology, Hepatology and Nutrition | - |
dc.citation.title | Pediatric Gastroenterology, Hepatology and Nutrition | - |
dc.citation.volume | 17 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 232 | - |
dc.citation.endPage | 238 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001943486 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Child | - |
dc.subject.keywordAuthor | Clostridium difficile | - |
dc.subject.keywordAuthor | Diarrhea | - |
dc.subject.keywordAuthor | Probiotics | - |
dc.identifier.url | https://pghn.org/DOIx.php?id=10.5223/pghn.2014.17.4.232 | - |
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