Oligopeptide complex for targeted non-viral gene delivery to adipocytes
DC Field | Value | Language |
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dc.contributor.author | Won, Young-Wook | - |
dc.contributor.author | Adhikary, Partho Protim | - |
dc.contributor.author | Lim, Kwang Suk | - |
dc.contributor.author | Kim, Hyung Jin | - |
dc.contributor.author | Kim, Jang Kyoung | - |
dc.contributor.author | Kim, Yong-Hee | - |
dc.date.accessioned | 2022-07-16T01:35:51Z | - |
dc.date.available | 2022-07-16T01:35:51Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2014-12 | - |
dc.identifier.issn | 1476-1122 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158463 | - |
dc.description.abstract | Commercial anti-obesity drugs acting in the gastrointestinal tract or the central nervous system have been shown to have limited effcacy and severe side effects. Anti-obesity drug development is thus focusing on targeting adipocytes that store excess fat. Here, we show that an adipocyte-targeting fusion-oligopeptide gene carrier consisting of an adipocyte-targeting sequence and 9-arginine (ATS-9R) selectively transfects mature adipocytes by binding to prohibitin. Injection of ATS-9R into obese mice confirmed specific binding of ATS-9R to fat vasculature, internalization and gene expression in adipocytes. We also constructed a short-hairpin RNA (shRNA) for silencing fatty-acid-binding protein 4 (shFABP4), a key lipid chaperone in fatty-acid uptake and lipid storage in adipocytes. Treatment of obese mice with ATS-9R/shFABP4 led to metabolic recovery and body-weight reduction (>20%). The ATS-9R/shFABP4 oligopeptide complex could prove to be a safe therapeutic approach to regress and treat obesity as well as obesity-induced metabolic syndromes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | Oligopeptide complex for targeted non-viral gene delivery to adipocytes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Hee | - |
dc.identifier.doi | 10.1038/NMAT4092 | - |
dc.identifier.scopusid | 2-s2.0-84939886544 | - |
dc.identifier.wosid | 000345432200020 | - |
dc.identifier.bibliographicCitation | NATURE MATERIALS, v.13, no.12, pp.1157 - 1164 | - |
dc.relation.isPartOf | NATURE MATERIALS | - |
dc.citation.title | NATURE MATERIALS | - |
dc.citation.volume | 13 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1157 | - |
dc.citation.endPage | 1164 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | CURRENT STRATEGIES | - |
dc.subject.keywordPlus | ANTIOBESITY DRUGS | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | SIRNA DELIVERY | - |
dc.subject.keywordPlus | NORMAL RATS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | PROHIBITIN | - |
dc.subject.keywordPlus | ADIPOKINES | - |
dc.identifier.url | https://www.nature.com/articles/nmat4092 | - |
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