Expression patterns of stromal MMP-2 and tumoural MMP-2 and-9 are significant prognostic factors in invasive ductal carcinoma of the breast
DC Field | Value | Language |
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dc.contributor.author | Min, Kyueng-Whan | - |
dc.contributor.author | Kim, Dong-Hoon | - |
dc.contributor.author | Do, Sung-Im | - |
dc.contributor.author | Kim, Kyungeun | - |
dc.contributor.author | Lee, Hyun Joo | - |
dc.contributor.author | Chae, Seoung Wan | - |
dc.contributor.author | Sohn, Jin Hee | - |
dc.contributor.author | Pyo, Jung-Soo | - |
dc.contributor.author | Oh, Young-Ha | - |
dc.contributor.author | Kim, Wan-Seop | - |
dc.contributor.author | Lee, So-Young | - |
dc.contributor.author | Oh, Sukjoong | - |
dc.contributor.author | Choi, Seon Hyeong | - |
dc.contributor.author | Park, Yong Lai | - |
dc.contributor.author | Park, Chan Heun | - |
dc.date.accessioned | 2022-07-16T01:36:18Z | - |
dc.date.available | 2022-07-16T01:36:18Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2014-12 | - |
dc.identifier.issn | 0903-4641 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158468 | - |
dc.description.abstract | Matrix metalloproteinases (MMPs) are matrix-degrading enzymes that play a pivotal role in aggressive behaviours, such as rapid tumour growth, invasion, and metastasis, of several types of solid tumours. In particular, stromal MMP-2 plays important roles in the progression of malignant tumours, but most clinical studies have focused on tumoural MMP-2 and -9 expression, and not stromal MMP-2 expression. One hundred and seventy-seven cases diagnosed as invasive ductal carcinoma of the breast between 2000 and 2005 were included in this study. Expressions of tumoural MMP-2 and -9 and stromal MMP-2 were analysed by immunostaining on a tissue microarray. Subsequently, the associations between those results and various clinicopathological parameters were evaluated. Stromal MMP-2 expression correlated significantly with clinicopathological parameters such as advanced T category, larger tumour size, high histological grade, tumour necrosis, ER- and PR-negative, and HER-2-positive (all p<0.05). In univariate and multivariate analyses, overall survival was linked with stromal MMP-2 expression as well as dual expression of stromal MMP-2 and tumoural MMP-2 and -9 (all p<0.05). Stromal MMP-2 expression may play a crucial role in predicting aggressive clinical behaviour in breast cancer patients. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Expression patterns of stromal MMP-2 and tumoural MMP-2 and-9 are significant prognostic factors in invasive ductal carcinoma of the breast | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Min, Kyueng-Whan | - |
dc.contributor.affiliatedAuthor | Oh, Young-Ha | - |
dc.identifier.doi | 10.1111/apm.12285 | - |
dc.identifier.scopusid | 2-s2.0-84921912941 | - |
dc.identifier.wosid | 000345512000006 | - |
dc.identifier.bibliographicCitation | APMIS, v.122, no.12, pp.1196 - 1206 | - |
dc.relation.isPartOf | APMIS | - |
dc.citation.title | APMIS | - |
dc.citation.volume | 122 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1196 | - |
dc.citation.endPage | 1206 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASE-2 MMP-2 | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | GELATINASE | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | SUBTYPES | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | MMP2 | - |
dc.subject.keywordAuthor | MMP9 | - |
dc.subject.keywordAuthor | stromal cell | - |
dc.subject.keywordAuthor | invasive ductal carcinoma | - |
dc.subject.keywordAuthor | breast | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.12285 | - |
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