Doxorubicin-Loaded Alginate-g-Poly(N-isopropylacrylamide) Micelles for Cancer Imaging and Therapy
- Authors
- Ahn, Dong-Gyun; Lee, Jangwook; Park, So-Young; Kwark, Young-Je; Lee, Kuen Yong
- Issue Date
- Dec-2014
- Publisher
- AMER CHEMICAL SOC
- Keywords
- micelle; alginate; cancer; diagnosis; therapy
- Citation
- ACS APPLIED MATERIALS & INTERFACES, v.6, no.24, pp.22069 - 22077
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACS APPLIED MATERIALS & INTERFACES
- Volume
- 6
- Number
- 24
- Start Page
- 22069
- End Page
- 22077
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158514
- DOI
- 10.1021/am505444c
- ISSN
- 1944-8244
- Abstract
- Chemotherapy is a widely adopted method for the treatment of cancer. However, its use is often limited due to side effects produced by anti-cancer drugs. Therefore, various drug carriers, including polymeric micelles, have been investigated to find a method to overcome this limitation. In this study, alginate-based, self-assembled polymeric micelles were designed and prepared using alginate-g-poly(N-isopropylacrylamide) (PNIPAAm). Amino-PNIPAAm was chemically introduced to the alginate backbone via carbodiimide chemistry. The resulting polymer was dissolved in distilled water at room temperature and formed self-assembled micelles at 37 degrees C. Characteristics of alginate-g-PNIPAAm micelles were dependent on the molecular weight of PNIPAAm, the degree of substitution, and the polymer concentration. Doxorubicin (DOX), a model anti-cancer drug, was efficiently encapsulated in alginate-g-PNIPAAm micelles, and sustained release of DOX from the micelles was achieved at 37 degrees C in vitro. These micelles accumulated at the tumor site of a tumor-bearing mouse model as a result of the enhanced permeability and retention effect. Interestingly, DOX-loaded alginate-g-PNIPAAm micelles showed excellent anti-cancer therapeutic efficacy in a mouse model without any significant side effects. This approach to designing and tailoring natural polymer-based systems to fabricate nanoparticles at human body temperature may provide a useful means for cancer imaging and therapy.
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