수용성 님추출물이 랫드의 간 독성에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 박경훈 | - |
dc.contributor.author | 윤현주 | - |
dc.contributor.author | 한범석 | - |
dc.contributor.author | 이제봉 | - |
dc.contributor.author | 정미혜 | - |
dc.contributor.author | 조남준 | - |
dc.contributor.author | 엄애선 | - |
dc.contributor.author | 백민경 | - |
dc.date.accessioned | 2022-07-16T01:57:12Z | - |
dc.date.available | 2022-07-16T01:57:12Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 1225-3537 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158641 | - |
dc.description.abstract | BACKGROUND: Azadirachta indica Extract(AIE)containing azadirachtin as active ingredient have been usedworldwide as environment-friendly organic material havingpest control properties. However, the extracts prepared withdifferent solvent and from different plant site is very diverseand have different toxicity. METHODS AND RESULTS: In this study, the four weekrepeated oral dose toxicity test of aqueous AIE inSprague-Dawley rats was carried out to investigate the toxiceffect of liver, main toxicity target organ of AIE. The maleand female rats were divided into 4 groups, respectively;control(0 g/Kg bw), low-dose group(0.5 g/Kg bw),middle-dose(1.0 g/Kg bw) and high-dose group(2.0 g/Kgbw). As a results, relative liver weight increased withdose-dependent of AIE(p<0.05). Serum LDH in allAIE-treated groups were significantly lower than thecontrol in male rats(p<0.05). However, serum GOT andGPT were significantly increased in all male AIE-treatedgroups in male rats(p<0.05) and, in particular, increase ofserum GPT in dose-dependent manner raise the possibilityof liver damage. Even through serum GLU was increasedsignificantly in high-dose group in male rats compared tocontrol, there were no significant differences of urinary GLUamong all groups(p<0.05). In addition, histopathologicalexamination of the liver did not reveal any lesions in allAIE-treated groups. CONCLUSION: In conclusion, 4 weeks of the repeated oraladministration of AIE 2.0 g/Kg to rats has resulted no toxicresponse in liver. Therefore, AIE was no indicated to haveany toxic effect in the SD rats, when it was orallyadministrated below the dosage 2.0 g/Kg/day for 4weeks. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 한국환경농학회 | - |
dc.title | 수용성 님추출물이 랫드의 간 독성에 미치는 영향 | - |
dc.title.alternative | Effects of Aqueous Azadirachta indica Extract on Hepatotoxicity in Rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 엄애선 | - |
dc.identifier.doi | 10.5338/KJEA.2014.33.3.395 | - |
dc.identifier.bibliographicCitation | 한국환경농학회지, v.33, no.4, pp.395 - 402 | - |
dc.relation.isPartOf | 한국환경농학회지 | - |
dc.citation.title | 한국환경농학회지 | - |
dc.citation.volume | 33 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 395 | - |
dc.citation.endPage | 402 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001940952 | - |
dc.description.journalClass | 2 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Azadirachta indica extract | - |
dc.subject.keywordAuthor | Hepatotoxicity | - |
dc.subject.keywordAuthor | Oral administration | - |
dc.subject.keywordAuthor | Rat | - |
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