Comparison of Morphine and Remifentanil on the Duration of Weaning from Mechanical Ventilationopen access
- Authors
- 이재명; 이성헌; 곽상현; 강현희; 이상학; 임재민; 정미애; 이영주; 임채만
- Issue Date
- Nov-2014
- Publisher
- 대한중환자의학회
- Keywords
- mechanical ventilation; morphine; remifentanil; ventilator weaning
- Citation
- Acute and Critical Care, v.29, no.4, pp.281 - 287
- Indexed
- KCI
OTHER
- Journal Title
- Acute and Critical Care
- Volume
- 29
- Number
- 4
- Start Page
- 281
- End Page
- 287
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158678
- DOI
- 10.4266/kjccm.2014.29.4.281
- ISSN
- 2586-6052
- Abstract
- Background: A randomized, multicenter, open‐label, parallel group study was performed to compare the effects of remifentanil and morphine as analgesic drugs on the duration of weaning time from mechanical ventilation (MV).
Methods: A total of 96 patients with MV in 6 medical and surgical intensive care units were randomly assigned to either, remifentanil (0.1‐0.2 mcg/kg/min, n = 49) or morphine (0.8‐35 mg/hr, n = 47) from the weaning start. The weaning time was defined as the total ventilation time minus the sum of controlled mode duration.
Results: Compared with the morphine group, the remifentanil‐based analgesic group showed a tendency of shorter weaning time (mean 143.9 hr, 89.7 hr, respectively: p = 0.069). Secondary outcomes such as total ventilation time, successful weaning rate at the 7th of MV day was similar in both groups. There was also no difference in the mortality rate at the 7th and 28th hospital day. Kaplan‐Meyer curve for weaning was not different between the two groups.
Conclusions: Remifentanil usage during the weaning phase tended to decrease weaning time compared with morphine usage.
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