Coxsackievirus B Infection Is Highly Related with Missed Abortion in Koreaopen access
- Authors
- Hwang, Jung Hye; Kim, Jeong Wook; Hwang, Ji Young; Lee, Kyung Min; Shim, Hye Min; Bae, Young Kyung; Paik, Seung Sam; Park, Hosun
- Issue Date
- Nov-2014
- Publisher
- YONSEI UNIV COLL MEDICINE
- Keywords
- Coxsackievirus; missed abortion; fetal anomaly
- Citation
- YONSEI MEDICAL JOURNAL, v.55, no.6, pp.1562 - 1567
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- YONSEI MEDICAL JOURNAL
- Volume
- 55
- Number
- 6
- Start Page
- 1562
- End Page
- 1567
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158706
- DOI
- 10.3349/ymj.2014.55.6.1562
- ISSN
- 0513-5796
- Abstract
- Purpose: This study investigated the possible relationship between viral infection and first trimester pregnancy loss. Materials and Methods: A prospective study was performed on 51 gravidas with missed abortion, fetal anomaly, pre-term delivery, and full-tern delivery at Hanyang University Hospital. Enteroviruses were detected by semi-nested reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry in abortive tissues and placentas. Enterovirus serotypes were confimied by genome sequencing. Hernesviruses were detected by PCR. Results: Coxsackievirus B3 (CVB3) was detected in 8 of 14 missed abortion cases, 1 of 27 full-term cases, and none of the 9 pre-term cases. Coxsackievirus B1 (CVB1) was detected in an encephalocele case. Herpes simplex virus type 1 was found in 4 full-term cases, 3 pre-term cases, and none of the missed abortion cases. Conclusion: The prevalence of CVB3 was significantly higher in missed abortion cases compared to full-term or pre-term delivery cases. CVB infection may therefore be an important etiological agent of missed abortion.
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