Presence of Sarcopenia and Its Rate of Change Are Independently Associated with Long-term Mortality in Patients with Liver Cirrhosis
DC Field | Value | Language |
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dc.contributor.author | Jeong, Jae Yoon | - |
dc.contributor.author | Lim, Sanghyeok | - |
dc.contributor.author | Sohn, Joo Hyun | - |
dc.contributor.author | Lee, Jae Gon | - |
dc.contributor.author | Jun, Dae Won | - |
dc.contributor.author | Kim, Yongsoo | - |
dc.date.accessioned | 2021-08-02T12:50:59Z | - |
dc.date.available | 2021-08-02T12:50:59Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/15871 | - |
dc.description.abstract | Background: Sarcopenia is associated with a poor prognosis in patients with liver cirrhosis. However, it is not known whether the rate of skeletal muscle depletion is also associated with a poor prognosis. We investigated the prognostic impact of the rate of skeletal muscle depletion in patients with liver cirrhosis. Methods: We included retrospectively all patients with liver cirrhosis who underwent both multiple computed tomography scans and hepatic venous pressure gradient (HVPG) measurements. Results: A total of 131 patients with liver cirrhosis were enrolled. The mean age of the patients was 53.7 years and alcoholic liver disease was the most common cause (61.8%). Sixty-four patients (48.9%) were diagnosed with sarcopenia. The median changes in skeletal muscle area per year (Delta SMA/y) were -0.89%. During a median follow-up period of 46.2 months (range, 3.4-87.6), 45 patients (34.4%) died. In multivariate analyses, age, Child-Pugh score, HVPG, presence of sarcopenia and Delta SMA/y were independently associated with mortality. Cumulative mortality was significantly higher in patients with Delta SMA/y < -2.4% than those with Delta SMA/y >= -2.4% (log-rank test, P < 0.001). Conclusion: Both the presence and rate of change of sarcopenia are independently associated with long-term mortality in patients with liver cirrhosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.title | Presence of Sarcopenia and Its Rate of Change Are Independently Associated with Long-term Mortality in Patients with Liver Cirrhosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sohn, Joo Hyun | - |
dc.contributor.affiliatedAuthor | Jun, Dae Won | - |
dc.contributor.affiliatedAuthor | Kim, Yongsoo | - |
dc.identifier.doi | 10.3346/jkms.2018.33.e299 | - |
dc.identifier.scopusid | 2-s2.0-85058191410 | - |
dc.identifier.wosid | 000452613500001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.33, no.50 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 33 | - |
dc.citation.number | 50 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002411843 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | VENOUS-PRESSURE GRADIENT | - |
dc.subject.keywordPlus | LENGTH-OF-STAY | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | SOLID TUMORS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | PREDICTOR | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | Liver Cirrhosis | - |
dc.subject.keywordAuthor | Sarcopenia | - |
dc.subject.keywordAuthor | Nutrition | - |
dc.subject.keywordAuthor | Mortality | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.identifier.url | https://jkms.org/DOIx.php?id=10.3346/jkms.2018.33.e299 | - |
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