Clinical characteristics of relapses and re-infections in Clostridium difficile infection
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, J. | - |
dc.contributor.author | Seo, M. -R. | - |
dc.contributor.author | Kang, J. O. | - |
dc.contributor.author | Kim, Y. | - |
dc.contributor.author | Hong, S. -P. | - |
dc.contributor.author | Pai, H. | - |
dc.date.accessioned | 2022-07-16T02:17:23Z | - |
dc.date.available | 2022-07-16T02:17:23Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 1198-743X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158782 | - |
dc.description.abstract | The purpose of this study was to identify factors associated with relapses or re-infections in patients with recurring Clostridium difficile infections (CDIs). From September 2008 to January 2012, cases with two or more isolates from consecutive CDI episodes were included. PCR-ribotyping and multilocus variable-number tandem-repeat analysis were performed using paired isolates. Among 473 patients, 68 (14.4%) experienced one to five recurrences. Fifty-one of these with two or more isolates from consecutive CDI episodes were included in the study; 25 (49%) were classified as relapses and 26 (51%) as re-infections. Recurrence interval was shorter in the relapse group (26.0 versus 67.5 p0.001), but more patients in the re-infection group were hospitalized during recurrence interval (53.8% versus 8.0%, p<0.001). Relapse rates in infections by ribotype 017, ribotype 018 and other ribotypes were 63.6%, 63.6% and 22.2%, respectively (p0.274, p0.069, and p0.005). In multivariate logistic regression, infections by ribotypes 017 and 018 were associated with CDI relapse (OR 4.77, 95% CI 1.02-22.31, p0.047; OR 11.49, 95% CI 2.07-63.72, p0.005). Conversely, admission during recurrence interval lowered the risk of relapse (OR 0.044, 95% CI 0.006-0.344, p0.003). In conclusion, relapse was more likely when infection was caused by PCR ribotypes 017 and 018. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Clinical characteristics of relapses and re-infections in Clostridium difficile infection | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, J. | - |
dc.contributor.affiliatedAuthor | Pai, H. | - |
dc.identifier.doi | 10.1111/1469-0691.12704 | - |
dc.identifier.scopusid | 2-s2.0-84917670799 | - |
dc.identifier.wosid | 000346337000046 | - |
dc.identifier.bibliographicCitation | CLINICAL MICROBIOLOGY AND INFECTION, v.20, no.11, pp.1198 - 1204 | - |
dc.relation.isPartOf | CLINICAL MICROBIOLOGY AND INFECTION | - |
dc.citation.title | CLINICAL MICROBIOLOGY AND INFECTION | - |
dc.citation.volume | 20 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1198 | - |
dc.citation.endPage | 1204 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | MULTILOCUS VARIABLE-NUMBER | - |
dc.subject.keywordPlus | MOLECULAR EPIDEMIOLOGY | - |
dc.subject.keywordPlus | BINARY TOXIN | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | COLITIS | - |
dc.subject.keywordAuthor | Clostridium difficile infection | - |
dc.subject.keywordAuthor | multilocus variable-number tandem-repeat analysis | - |
dc.subject.keywordAuthor | PCR ribotyping | - |
dc.subject.keywordAuthor | recurrence | - |
dc.subject.keywordAuthor | re-infection | - |
dc.subject.keywordAuthor | relapse | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1198743X14653180?via%3Dihub | - |
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