VEGF/VEGFR2 and PDGF-B/PDGFR-β expression in non-metastatic renal cell carcinoma: a retrospective study in 1,091 consecutive patients
DC Field | Value | Language |
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dc.contributor.author | Song, Sang Hoon | - |
dc.contributor.author | Jeong, In Gab | - |
dc.contributor.author | You, Dalsan | - |
dc.contributor.author | Hong, Jun Hyuk | - |
dc.contributor.author | Hong, Bumsik | - |
dc.contributor.author | Song, Cheryn | - |
dc.contributor.author | Jung, Woon Yong | - |
dc.contributor.author | Cho, Young Mee | - |
dc.contributor.author | Ahn, Hanjong | - |
dc.contributor.author | Kim, Choung-Soo | - |
dc.date.accessioned | 2022-07-16T02:33:25Z | - |
dc.date.available | 2022-07-16T02:33:25Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2014-10 | - |
dc.identifier.issn | 19362625 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/158885 | - |
dc.description.abstract | Purpose: We aimed to investigate the correlations between the expression of VEGF, PDGF-B, and their receptors (VEGFR2 and PDGFR-beta) with pathologic stage or cell type in non-metastatic renal cell carcinoma. Materials and methods: VEGF, VEGFR2, PDGF-B, and PDGFR-protein expression were evaluated immunohistochemically in prospectively collected 1,423 tumour samples obtained during radical or partial nephrectomy at a tertiary referral center. Intensity of expression was quantified on a scale of 0 to 3, and was compared among renal cell carcinoma cell types. Results: The study cohort consisted of 1,091 patients, of mean age 54 years, including 968 (88.7%) with clear cell, 82 (7.5%) with papillary, 31 (2.8%) with chromophobe, 4 (0.4%) with unclassified, and 6 (0.5%) with other types of renal cell carcinoma. VEGF expression increased with higher T and N stage and Fuhrman nuclear grade. PDGFR-expression was highest in clear cell renal cell carcinoma, whereas VEGF and PDGF-B expression were highest in papillary renal cell carcinoma. After adjusting for T stage and Fuhrman nuclear grade using multivariate logistic regression analysis, VEGF (OR = 3.57, P < 0.001), VEGFR2 (OR = 1.82, P = 0.017), and PDGF-B (OR = 2.46, P = 0.019) expression were significantly greater in papillary than in clear cell type. Conclusions: Our results indicate that the cytoplasmic expression of VEGF, VEGFR2, PDGF-B, and PDGFR-in RCC tumour cells is different in various pathologic stage and cell type. Notably, VEGF and PDGF-B expression are higher in papillary than in clear cell renal cell carcinoma. Further studies using quantitative measurement of proangiogenic factors in tumour cell are needed. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | E-CENTURY PUBLISHING CORP | - |
dc.title | VEGF/VEGFR2 and PDGF-B/PDGFR-β expression in non-metastatic renal cell carcinoma: a retrospective study in 1,091 consecutive patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Woon Yong | - |
dc.identifier.scopusid | 2-s2.0-84920114706 | - |
dc.identifier.wosid | 000348345200038 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, v.7, no.11, pp.7681 - 7689 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | - |
dc.citation.volume | 7 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 7681 | - |
dc.citation.endPage | 7689 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | MESSENGER-RNA EXPRESSION | - |
dc.subject.keywordPlus | FACTOR VEGF | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordAuthor | Carcinoma | - |
dc.subject.keywordAuthor | renal cell | - |
dc.subject.keywordAuthor | vascular endothelial growth factor A | - |
dc.subject.keywordAuthor | vascular endothelial growth factor receptor-2 | - |
dc.identifier.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270555/ | - |
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