Overexpression of Human GATA-1 and GATA-2 Interferes with Spine Formation and Produces Depressive Behavior in Rats
DC Field | Value | Language |
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dc.contributor.author | Choi, Miyeon | - |
dc.contributor.author | Wang, Sung Eun | - |
dc.contributor.author | Ko, Seung Yeon | - |
dc.contributor.author | Kang, Hyo Jung | - |
dc.contributor.author | Chae, Seung Yeun | - |
dc.contributor.author | Lee, Seung Hoon | - |
dc.contributor.author | Kim, Yong-Seok | - |
dc.contributor.author | Duman, Ronald S. | - |
dc.contributor.author | Son, Hyeon | - |
dc.date.accessioned | 2022-07-16T02:52:52Z | - |
dc.date.available | 2022-07-16T02:52:52Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2014-10 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/159027 | - |
dc.description.abstract | Functional consequences to which vertebrate GATA transcription factors contribute in the adult brain remain largely an open question. The present study examines how human GATA-1 and GATA-2 (hGATA-1 and hGATA-2) are linked to neuronal differentiation and depressive behaviors in rats. We investigated the effects of adeno-associated viral expression of hGATA-1 and hGATA-2 (AAV-hGATA1 and AAV-hGATA2) in the dentate gyrus (DG) of the dorsal hippocampus on dendrite branching and spine number. We also examined the influence of AAV-hGATA1 and AAV-hGATA2 infusions into the dorsal hippocampus on rodent behavior in models of depression. Viral expression of hGATA-1 and hGATA-2 cDNA in rat hippocampal neurons impaired dendritic outgrowth and spine formation. Moreover, viral-mediated expression of hGATA-1 and hGATA-2 in the dorsal hippocampus caused depressive-like deficits in the forced swim test and learned helplessness models of depression, and decreased the expression of several synapse-related genes as well as spine number in hippocampal neurons. Conversely, shRNA knockdown of GATA-2 increased synapse-related gene expression, spine number, and dendrite branching. The results demonstrate that hGATA-1 and hGATA-2 expression in hippocampus is sufficient to cause depressive like behaviors that are associated with reduction in spine synapse density and expression of synapserelated genes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Overexpression of Human GATA-1 and GATA-2 Interferes with Spine Formation and Produces Depressive Behavior in Rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Seok | - |
dc.contributor.affiliatedAuthor | Son, Hyeon | - |
dc.identifier.doi | 10.1371/journal.pone.0109253 | - |
dc.identifier.scopusid | 2-s2.0-84908587621 | - |
dc.identifier.wosid | 000343662800007 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.9, no.10, pp.1 - 10 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 9 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | ANTIDEPRESSANT ACTIONS | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | DENDRITIC SPINES | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | REGULATOR | - |
dc.identifier.url | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109253 | - |
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