Anti-Obesity Effects of Granulocyte-Colony Stimulating Factor in Otsuka-Long-Evans-Tokushima Fatty Rats
DC Field | Value | Language |
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dc.contributor.author | Lee, Yonggu | - |
dc.contributor.author | Song, Yi-Sun | - |
dc.contributor.author | Fang, Cheng-Hu | - |
dc.contributor.author | So, Byung-Im | - |
dc.contributor.author | Park, Jun-Young | - |
dc.contributor.author | Joo, Hyun-Woo | - |
dc.contributor.author | Park, In-Hwa | - |
dc.contributor.author | Shen, Guang-Yin | - |
dc.contributor.author | Shin, Jeong-Hun | - |
dc.contributor.author | Kim, Hyuck | - |
dc.contributor.author | Ahn, You-Heon | - |
dc.contributor.author | Kim, Kyung-Soo | - |
dc.date.accessioned | 2022-07-16T03:45:15Z | - |
dc.date.available | 2022-07-16T03:45:15Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/159459 | - |
dc.description.abstract | Granulocyte-colony stimulating factor (G-CSF) has molecular structures and intracellular signaling pathways that are similar to those of leptin and ciliary neurotropic factor (CNTF). It also has immune-modulatory properties. Given that leptin and CNTF play important roles in energy homeostasis and that obesity is an inflammatory condition in adipose tissue, we hypothesized that G-CSF could also play a role in energy homeostasis. We treated 12 38-week-old male Otsuka-Long-Evans-Tokushima fatty rats (OLETF, diabetic) and 12 age-matched male Long-Evans-Tokushima rats (LETO, healthy) with 200 mu g/day G-CSF or saline for 5 consecutive days. Body weight reduction was greater in G-CSF-treated OLETF (G-CSF/OLETF) than saline-treated OLETF (saline/OLETF) following 8 weeks of treatment (-6.9 +/- 1.6% vs. -3.1 +/- 2.2%, p<0.05). G-CSF treatment had no effect on body weight in LETO or on food intake in either OLETF or LETO. Body fat in G-CSF/OLETF was more reduced than in saline/OLETF (-32.2 +/- 3.1% vs. -20.8 +/- 6.2%, p<0.05). Energy expenditure was higher in G-CSF/OLETF from 4 weeks after the treatments than in saline/OLETF. Serum levels of cholesterol, triglyceride, interleukin-6 and tumor necrosis factor-a were lower in G-CSF/OLETF than in saline/OLETF. Uncoupling protein-1 (UCP-1) expression in brown adipose tissue (BAT) was higher in G-CSF/OLETF than in saline/OLETF, but was unaffected in LETO. Immunofluorescence staining and PCR results revealed that G-CSF receptors were expressed in BAT. In vitro experiments using brown adipocyte primary culture revealed that G-CSF enhanced UCP-1 expression from mature brown adipocytes via p38 mitogen-activated protein kinase pathway. In conclusion, G-CSF treatment reduced body weight and increased energy expenditure in a diabetic model, and enhanced UCP-1 expression and decreased inflammatory cytokine levels may be associated with the effects of G-CSF treatment. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Anti-Obesity Effects of Granulocyte-Colony Stimulating Factor in Otsuka-Long-Evans-Tokushima Fatty Rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Yonggu | - |
dc.contributor.affiliatedAuthor | Shin, Jeong-Hun | - |
dc.contributor.affiliatedAuthor | Kim, Hyuck | - |
dc.identifier.doi | 10.1371/journal.pone.0105603 | - |
dc.identifier.scopusid | 2-s2.0-84938226503 | - |
dc.identifier.wosid | 000341106100094 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.9, no.8, pp.1 - 11 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 9 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | CILIARY NEUROTROPHIC FACTOR | - |
dc.subject.keywordPlus | UNCOUPLING PROTEIN-1 UCP1 | - |
dc.subject.keywordPlus | TYPE-2 DIABETES-MELLITUS | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | BROWN ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | FACTOR G-CSF | - |
dc.subject.keywordPlus | BODY-WEIGHT | - |
dc.subject.keywordPlus | FOOD-INTAKE | - |
dc.subject.keywordPlus | ENERGY-EXPENDITURE | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.identifier.url | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105603 | - |
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