Incidence, Risk Factors, and Long-Term Outcomes of Sclerotic Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation
DC Field | Value | Language |
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dc.contributor.author | Uhm, Ji eun | - |
dc.contributor.author | Hamad, Nada | - |
dc.contributor.author | Shin, Elizabeth M. | - |
dc.contributor.author | Michelis, Fotios | - |
dc.contributor.author | Shanavas, Mohamed | - |
dc.contributor.author | Gupta, Vikas | - |
dc.contributor.author | Kuruvilla, John | - |
dc.contributor.author | Lipton, Jeffrey H. | - |
dc.contributor.author | Messner, Hans A. | - |
dc.contributor.author | Seftel, Matthew | - |
dc.contributor.author | Kim, Dong Hwan | - |
dc.date.accessioned | 2022-07-16T03:49:46Z | - |
dc.date.available | 2022-07-16T03:49:46Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2014-07 | - |
dc.identifier.issn | 1083-8791 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/159514 | - |
dc.description.abstract | Sclerotic chronic graft-versus-host disease (sclGVHD) is associated with significant morbidity and a poor quality of life. We reviewed 502 patients diagnosed with chronic GVHD and analyzed the incidence and risk factors of sclGVHD and long-term outcomes and immunosuppressive therapy (IST) cessation in patients with sclGVHD. With a median onset at 18 months the cumulative incidence of sclGVHD was estimated at 22.6% at 5 years (95% confidence interval, 18.6% to 26.8%). Univariate and multivariate analysis identified 2 risk factors for sclGVHD: non-T cell depletion (hazard ratio [HR] 9.09, P ˂ .001) and peripheral blood stem cell (HR 3.87, P ˂ .001). Overall survival (OS) at 5 years was significantly better in the scIGVHD group (88.1%) compared with the non-sclGVHD group (62.7%; P ˂ .001), as were nonrelapse mortality (7.3% versus 21.5% at 5 years) and relapse rates (9.1% versus 19.3% at 5 years). There was no difference in the rate of IST cessation at 5 years (44.8% versus 49.9%, P = .312), but there was a trend of longer IST duration in the sclGVHD group compared with the non-sclGVHD group (median 71.6 months versus 62.9 months). In conclusion, T cell depletion and graft source affect the risk of sclGVHD. SclGVHD did not adversely affect long-term outcomes or IST duration. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Incidence, Risk Factors, and Long-Term Outcomes of Sclerotic Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Uhm, Ji eun | - |
dc.identifier.doi | 10.1016/j.bbmt.2014.07.001 | - |
dc.identifier.scopusid | 2-s2.0-84908080155 | - |
dc.identifier.wosid | 000343364300014 | - |
dc.identifier.bibliographicCitation | BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, v.20, no.11, pp.1751 - 1757 | - |
dc.relation.isPartOf | BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | - |
dc.citation.title | BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | - |
dc.citation.volume | 20 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1751 | - |
dc.citation.endPage | 1757 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | REMISSION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | GVHD | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordAuthor | Chronic graft-versus-host | - |
dc.subject.keywordAuthor | disease | - |
dc.subject.keywordAuthor | Sclerosis | - |
dc.subject.keywordAuthor | Allogeneic hematopoietic stem | - |
dc.subject.keywordAuthor | cell transplantation | - |
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