Refillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane
- Authors
- So, Hongyun; Seo, Young Ho; Pisano, Albert P.
- Issue Date
- Jul-2014
- Publisher
- AMER INST PHYSICS
- Citation
- BIOMICROFLUIDICS, v.8, no.4, pp.1 - 11
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOMICROFLUIDICS
- Volume
- 8
- Number
- 4
- Start Page
- 1
- End Page
- 11
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/159522
- DOI
- 10.1063/1.4893912
- ISSN
- 1932-1058
- Abstract
- We report a refillable and valveless drug delivery device actuated by an external magnetic field for on- demand drug release to treat localized diseases. The device features a pear-shaped viscoelastic magnetic membrane inducing asymmetrical deflection and consecutive touchdown motion to the bottom of the dome-shaped drug reservoir in response to a magnetic field, thus achieving controlled discharge of the drug. Maximum drug release with 1861.5 mu g per actuation was achieved under a 500mT magnetic flux density, and various controlled drug doses were investigated with the combination of the number of accumulated actuations and the strength of the magnetic field.
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