Gene expression profile predicting the response to anti-TNF treatment in patients with rheumatoid arthritis; analysis of GEO datasets
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae-Hwan | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Ji, Jong Bae | - |
dc.date.accessioned | 2022-07-16T03:56:26Z | - |
dc.date.available | 2022-07-16T03:56:26Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2014-07 | - |
dc.identifier.issn | 1297-319X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/159581 | - |
dc.description.abstract | Objectives: Anti-tumor necrosis factor (TNF) therapy is the treatment of choice for rheumatoid arthritis (RA) patients in whom standard disease-modifying anti-rheumatic drugs are ineffective. However, a substantial proportion of RA patients treated with anti-TNF agents do not show a significant clinical response. Therefore, biomarkers predicting response to anti-TNF agents are needed. Recently, gene expression profiling has been applied in research for developing such biomarkers. Methods: We compared gene expression profiles reported by previous studies dealing with the responsiveness of anti-TNF therapy in RA patients and attempted to identify differentially expressed genes (DEGs) that discriminated between responders and non-responders to anti-TNF therapy. We used microarray datasets available at the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO). Results: This analysis included 6 studies and 5 sets of microarray data that used peripheral blood samples for identification of DEGs predicting response to anti-TNF therapy. We found little overlap in the DEGs that were highly ranked in each study. Three DEGs including IL2RB, SH2D2A and G0S2 appeared in more than 1 study. In addition, a meta-analysis designed to increase statistical power found one DEG, G0S2 by the Fisher's method. Conclusion: Our finding suggests the possibility that G0S2 plays as a biomarker to predict response to anti-TNF therapy in patients with rheumatoid arthritis. Further investigations based on larger studies are therefore needed to confirm the significance of G0S2 in predicting response to anti-TNF therapy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | - |
dc.title | Gene expression profile predicting the response to anti-TNF treatment in patients with rheumatoid arthritis; analysis of GEO datasets | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Hwan | - |
dc.identifier.doi | 10.1016/j.jbspin.2014.01.013 | - |
dc.identifier.scopusid | 2-s2.0-84904135761 | - |
dc.identifier.wosid | 000339706500009 | - |
dc.identifier.bibliographicCitation | JOINT BONE SPINE, v.81, no.4, pp.325 - 330 | - |
dc.relation.isPartOf | JOINT BONE SPINE | - |
dc.citation.title | JOINT BONE SPINE | - |
dc.citation.volume | 81 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 325 | - |
dc.citation.endPage | 330 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | WHITE BLOOD-CELLS | - |
dc.subject.keywordPlus | MICROARRAY METAANALYSIS | - |
dc.subject.keywordPlus | GENOMIC METAANALYSIS | - |
dc.subject.keywordPlus | QUALITY-CONTROL | - |
dc.subject.keywordPlus | INFLIXIMAB | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | ADALIMUMAB | - |
dc.subject.keywordPlus | SIGNATURE | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.subject.keywordAuthor | Anti-TNF | - |
dc.subject.keywordAuthor | Response | - |
dc.subject.keywordAuthor | Microarray | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1297319X14000347?via%3Dihub | - |
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