Allogeneic hematopoietic cell transplantation without total body irradiation from unrelated donor in adult patients with idiopathic aplastic anemia: Fludarabine versus cyclophosphamide-ATG
DC Field | Value | Language |
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dc.contributor.author | Kim, Hawk | - |
dc.contributor.author | Lee, Kyoo-Hyung | - |
dc.contributor.author | Kim, Inho | - |
dc.contributor.author | Sohn, Sang Kyun | - |
dc.contributor.author | Jung, Chul Won | - |
dc.contributor.author | Joo, Young Don | - |
dc.contributor.author | Kim, Sung-Hyun | - |
dc.contributor.author | Kim, Byung Soo | - |
dc.contributor.author | Choi, Jung Hye | - |
dc.contributor.author | Kwak, Jae-Yong | - |
dc.contributor.author | Kim, Min Kyoung | - |
dc.contributor.author | Bae, Sung Hwa | - |
dc.contributor.author | Shin, Ho Jin | - |
dc.contributor.author | Won, Jong-Ho | - |
dc.contributor.author | Lee, Won Sik | - |
dc.contributor.author | Oh, Sukjoong | - |
dc.contributor.author | Kim, Hyo Jung | - |
dc.contributor.author | Park, Jae-Hoo | - |
dc.date.accessioned | 2022-07-16T04:06:40Z | - |
dc.date.available | 2022-07-16T04:06:40Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2014-07 | - |
dc.identifier.issn | 0145-2126 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/159634 | - |
dc.description.abstract | Total body irradiation (TBI) has traditionally been used in the conditioning regimen for allogenetic hematopoietic stem cell transplantation (alloHCT) from an unrelated donor (u-HCT). However, patients are increasingly receiving a fludarabine-based conditioning regimen without TBI, as it seemed less toxic than TBI. We need to know the clinical results of non-TBI u-HCT treatments. We retrospectively investigated the clinical outcomes of allogenetic hematopoietic cell transplantation (alloHCT) from an unrelated donor without TBI (non-TBI u-HCT) and compared the clinical outcomes of fludarabine-based (FLU group) and cyclophosphamide-ATG (Cy-ATG group) conditioning regimens. Sixty-one patients received the non-TBI conditioning regimen for u-HCT (32 in the FLU group and 29 in the Cy-ATG group). The cumulative incidence of neutrophil engraftment at 30 days, platelet > 20 K/mu L at 30 days, acute graft-versus host disease (aGvHD) at 100 days, and chronic GvHD (cGvHD) at 2 years were 87.01%, 65.57%, 35.20%, and 26.64%, respectively. However, transplantation outcomes and overall survival rates did not differ between the FLU and Cy-ATG groups. Only infused CD34+ cells >3 x 10(6) kg(-1) was identified as a favorable factor for survival in the multivariate analysis. In conclusion, non-TBI u-HCT was feasible and there was no difference between the FLU and Cy-ATG groups in terms of transplantation outcomes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Allogeneic hematopoietic cell transplantation without total body irradiation from unrelated donor in adult patients with idiopathic aplastic anemia: Fludarabine versus cyclophosphamide-ATG | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Jung Hye | - |
dc.identifier.doi | 10.1016/j.leukres.2014.01.002 | - |
dc.identifier.scopusid | 2-s2.0-84902120491 | - |
dc.identifier.wosid | 000339339400003 | - |
dc.identifier.bibliographicCitation | LEUKEMIA RESEARCH, v.38, no.7, pp.730 - 736 | - |
dc.relation.isPartOf | LEUKEMIA RESEARCH | - |
dc.citation.title | LEUKEMIA RESEARCH | - |
dc.citation.volume | 38 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 730 | - |
dc.citation.endPage | 736 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.subject.keywordPlus | BONE-MARROW-TRANSPLANTATION | - |
dc.subject.keywordPlus | MATCHED SIBLING DONORS | - |
dc.subject.keywordPlus | VERSUS-HOST-DISEASE | - |
dc.subject.keywordPlus | SAA WORKING PARTY | - |
dc.subject.keywordPlus | PERIPHERAL-BLOOD | - |
dc.subject.keywordPlus | ANTITHYMOCYTE GLOBULIN | - |
dc.subject.keywordPlus | VENOOCCLUSIVE DISEASE | - |
dc.subject.keywordPlus | CONDITIONING REGIMEN | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | REJECTION | - |
dc.subject.keywordAuthor | Unrelated donor | - |
dc.subject.keywordAuthor | Total body irradiation | - |
dc.subject.keywordAuthor | Aplastic anemia | - |
dc.subject.keywordAuthor | Allogeneic hematopoietic stem cell transplantation | - |
dc.subject.keywordAuthor | Fludarabinea | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0145212614000058?via%3Dihub | - |
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