The changes of PCR ribotype and antimicrobial resistance of Clostridium difficile in a tertiary care hospital over 10 years
DC Field | Value | Language |
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dc.contributor.author | Lee, Jong-Han | - |
dc.contributor.author | Lee, Yang soon | - |
dc.contributor.author | Lee, Kyungwon | - |
dc.contributor.author | Riley, Thomas V. | - |
dc.contributor.author | Kim, Heejung | - |
dc.date.accessioned | 2022-07-16T04:19:29Z | - |
dc.date.available | 2022-07-16T04:19:29Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 0022-2615 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/159691 | - |
dc.description.abstract | The aims of this study were to investigate any change in PCR ribotypes and to determine the antimicrobial resistance of common PCR ribotypes over a 10-year period in a tertiary care hospital. We conducted PCR ribotyping, antimicrobial susceptibility testing and DNA gyrase sequencing to identify changes in 1407 Clostridium difficile non-duplicated isolates obtained between 2000 and 2009. A total of 74 different ribotypes were found. The most prevalent ribotype was ribotype 001 (26.1 %). The prevalence of ribotype 017 was 17% and that of ribotype 014/020 was 9.6 %. Ribotyping showed that the prevalence of ribotype 001 decreased and the prevalence of ribotypes 017, 014/020 and 018 increased over the 10 years. Antimicrobial resistance rates in prevalent ribotypes were: clindamycin, 81 %; cefotetan, 19%; moxifloxacin, 42 %; imipenem, 8%; ciprofloxacin, 100% and erythromycin, 80 %. Ribotype 018 showed greater antimicrobial resistance than other ribotypes. All ribotype 018 strains showing moxifloxacin resistance had a substitution of a gyrA coding amino acid (Thr82 to Ile). This study will help the understanding of PCR ribotype trends and antimicrobial resistance of C. difficile in Korea. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SOC GENERAL MICROBIOLOGY | - |
dc.title | The changes of PCR ribotype and antimicrobial resistance of Clostridium difficile in a tertiary care hospital over 10 years | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Yang soon | - |
dc.identifier.doi | 10.1099/jmm.0.072082-0 | - |
dc.identifier.scopusid | 2-s2.0-84901365137 | - |
dc.identifier.wosid | 000338815500007 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICAL MICROBIOLOGY, v.63, no.6, pp.819 - 823 | - |
dc.relation.isPartOf | JOURNAL OF MEDICAL MICROBIOLOGY | - |
dc.citation.title | JOURNAL OF MEDICAL MICROBIOLOGY | - |
dc.citation.volume | 63 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 819 | - |
dc.citation.endPage | 823 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | BINARY TOXIN | - |
dc.subject.keywordPlus | MOXIFLOXACIN | - |
dc.subject.keywordPlus | INFECTIONS | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | GYRB | - |
dc.identifier.url | https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.072082-0 | - |
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