Optimal precurarizing dose of rocuronium to decrease fasciculation and myalgia following succinylcholine administration
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyu Nam | - |
dc.contributor.author | Kim, Kyo Sang | - |
dc.contributor.author | Choi, Hoon Il | - |
dc.contributor.author | Jeong, Ji Seon | - |
dc.contributor.author | Lee, Hee-Jong | - |
dc.date.accessioned | 2022-07-16T04:26:34Z | - |
dc.date.available | 2022-07-16T04:26:34Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 2005-6419 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/159782 | - |
dc.description.abstract | Background: Succinylcholine commonly produces frequent adverse effects, including muscle fasciculation and myalgia. The current study identified the optimal dose of rocuronium to prevent succinylcholine-induced fasciculation and myalgia and evaluated the influence of rocuronium on the speed of onset produced by succinylcholine. Methods: This randomized, double-blinded study was conducted in 100 patients randomly allocated into five groups of 20 patients each. Patients were randomized to receive 0.02, 0.03, 0.04, 0.05 and 0.06 mg/kg rocuronium as a precurarizing dose. Neuromuscular monitoring after each precurarizing dose was recorded from the adductor pollicis muscle using acceleromyography with train-of-four stimulation of the ulnar nerve. All patients received succinylcholine 1.5 mg/kg at 2 minutes after the precurarization, and were assessed the incidence and severity of fasciculations, while myalgia was assessed at 24 hours after surgery. Results: The incidence and severity of visible muscle fasciculation was significantly less with increasing the amount of precurarizing dose of rocuronium (P < 0.001). Those of myalgia tend to decrease according to increasing the amount of precurarizing dose of rocuronium, but there was no significance (P = 0.072). The onset time of succinylcholine was significantly longer with increasing the amount of precurarizing dose of rocuronium (P < 0.001). Conclusions: Precurarization with 0.04 mg/kg rocuronium was the optimal dose considering the reduction in the incidence and severity of fasciculation and myalgia with acceptable onset time, and the safe and effective precurarization. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Korean Society of Anesthesiologists | - |
dc.title | Optimal precurarizing dose of rocuronium to decrease fasciculation and myalgia following succinylcholine administration | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Kyu Nam | - |
dc.identifier.doi | 10.4097/kjae.2014.66.6.451 | - |
dc.identifier.scopusid | 2-s2.0-84904070241 | - |
dc.identifier.bibliographicCitation | Korean Journal of Anesthesiology, v.66, no.6, pp.451 - 456 | - |
dc.relation.isPartOf | Korean Journal of Anesthesiology | - |
dc.citation.title | Korean Journal of Anesthesiology | - |
dc.citation.volume | 66 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 451 | - |
dc.citation.endPage | 456 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001883142 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | rocuronium | - |
dc.subject.keywordPlus | suxamethonium | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | arterial pressure | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | bispectral index | - |
dc.subject.keywordPlus | capnometry | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | double blind procedure | - |
dc.subject.keywordPlus | drug induced disease | - |
dc.subject.keywordPlus | electrocardiography | - |
dc.subject.keywordPlus | endotracheal intubation | - |
dc.subject.keywordPlus | fasciculation | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | muscle rigidity | - |
dc.subject.keywordPlus | myalgia | - |
dc.subject.keywordPlus | neuromuscular function | - |
dc.subject.keywordPlus | optimal drug dose | - |
dc.subject.keywordPlus | oxygen saturation | - |
dc.subject.keywordPlus | premedication | - |
dc.subject.keywordPlus | randomized controlled trial | - |
dc.subject.keywordAuthor | Fasciculation | - |
dc.subject.keywordAuthor | Myalgia | - |
dc.subject.keywordAuthor | Neuromuscular blockade | - |
dc.subject.keywordAuthor | Precurarization | - |
dc.subject.keywordAuthor | Rocuronium | - |
dc.subject.keywordAuthor | Succinylcholine | - |
dc.identifier.url | https://ekja.org/journal/view.php?doi=10.4097/kjae.2014.66.6.451 | - |
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